Objective: To investigate the gender and age characteristics of primary liver cancer patients in Yichang Central People's HospitalCase colle
Objective: To investigate the gender and age characteristics of primary liver cancer patients in Yichang Central People's Hospital
Case collection method:
The hospital electronic case management system, 1) for diagnosis of primary liver cancer, 2) admission time period from October 1, 2003 to February 20, 2012; for 3004 cases with primary liver cancer patients, a total of 1444 people. All the patients were analyzed for the first time.
About 110 thousand people died of liver cancer in China every year, including 80 thousand men, 30 thousand women; median age towards the direction of the young transformation in China was 40 to 50 years; in China, according to the 27 provinces (cities, districts) of 1990 ~ 1992 sampling area residents death rate of malignant tumor, liver cancer mortality of malignant tumor mortality second, 20.37/10 million (29.01/10 million 11.21/10 million men, women), in Jiangsu Qidong, Fujian Shunde, Guangxi Guangdong Tongan, Fusui, the mortality rate of 30/10 million.
The positive rate of HBsAg in 1000 cases of hepatocellular carcinoma in the Department of hepatobiliary surgery of Second Military Medical University East 68.6%, Zhongshan Hospital of Shanghai city in 992 cases of hepatocellular carcinoma with positive rate of HBsAg was 69.1%; the positive rate of HBsAg in hepatocellular carcinoma in Taiwan reported 80%;
1 male and female patients with primary liver cancer: a total of 1196 men (n = 82.8%) and women (n = 17.2%) (), with a male to female ratio of 4.82:1. There are reports that the gender differences in the incidence of HCC is significant, the differences between men and women in areas of 8:1, the low incidence area of 2-3:1, the national data for 3:1, suggesting that primary hepatocellular carcinoma in Yichang generally belongs to the low region, the proportion of male patients with hepatocellular carcinoma is slightly higher than the national level;
2 the age of onset ranged from 12 to 88 years old, the average age was 42 years old; according to the age distribution were: 12 years old -20 years old 4 cases (1.7%); 21 years old -30 years old 29 cases (2%); 31 years old -40 years old 205 cases (14.2%); 41 -50 years old 401 cases (27.8%); 51 years old -60 years old 427 cases (29.6%); 61 years old -70 years old 250 cases (17.3%); 71 years old -80 years old 104 cases (7.2%); 81 years old in 24 cases (1.7%); indicated that liver cancer accounted for 3.17% in less than 30 years old, 30 years old to 70 years old: enter the relatively high age stage, of which 40 to 60 years old the highest risk probability.
3 to estimate the risk of liver cancer in Yichang male / female patients with hepatitis B is 2.41:1, the estimation process is as follows:
The primary liver cancer in our country mainly occurs on the basis of chronic HBV infection. In our country, 70% of patients with primary liver cancer have a chronic HBV infection. (in our hospital in patients with primary hepatocellular carcinoma with chronic HBV infection, the proportion of patients pending further investigation, because the information obtained by electronic medical records can not directly provide each case whether patients with chronic HBV infection, according to medical records also need to check one by one, involving huge workload, non personal ability short and needs to be verified in the future to gradually I assume these), the patients were infected with chronic hepatitis b;
Men and women with chronic HBV infection prevalence estimates: provide data in accordance with the 2002 national epidemiological survey of hepatitis B infection, pooled age groups over the age of 15 of all respondents with chronic HBV infection rate of =3172/35571=8.91%, according to the report pointed out that in the over 15 age group in 2002 the national chronic HBV infection rate and the infection rate of chronic hepatitis B in 1992 no obvious changes compared (9.2% in 1992); the 2002 data showed that "3 year old age group, men and women with chronic hepatitis B infection rate were 8.12% and 6.85%, the proportion was 1.2, suggesting the presence of male patients with chronic hepatitis B infection rate is higher than the female. The report did not mention the age group above the age of 15 chronic HBV infected men and women the prevalence data, considering the "3 age group of chronic HBV infection rate is lower than the age group above the age of 15, and due to hepatitis B vaccination did not effect gap between men and women reported that the number of Gu estimation can reduce according to the epidemic rate the gap between men and women infected with HBV over 15 years old age group.
According to the famous scholar and Professor GUI Yan China's exchange of personal information, he told me that in the 50 thousand provinces of the pregnant women with chronic HBV infection prevalence rate is about 6%, can be predicted by theory of men with chronic HBV prevalence rate is around 12% (this total around 9%), can be further estimated in the 15 age group of men and women the prevalence of chronic HBV in the proportion of about 2:1, more in line with the local Yichang 15 years old age group the prevalence of chronic HBV.
Primary liver cancer and the ratio of =4.82:1 for chronic hepatitis B in Yichang City local infection, and chronic HBV infection prevalence ratio of 2:1, so the actual risk of primary liver cancer in male patients with chronic HBV will be 2.41 times higher than women, similar to the national data.
Fang Qing doctor:
This is just the beginning of a work, with the gradual progress of follow-up follow-up work on liver cancer, cirrhosis, and hepatitis patients, the data will gradually replace the rational speculation became the core of health science. This rough investigation clearly reflects the incidence of HCC in every age stage and the difference in the proportion of patients with gender, provides a basis for future epidemiological perspective to guide the clinic practice of hepatitis B. The analysis will focus on the output of funds and treatment effect, practical significance may be clearly revealed liver cancer screening. In addition, I am very concerned about whether the hepatitis B patients with liver cancer from 2 years old and the source of infection in patients with hepatitis B infection the proportion of patients over the age of 2, and previous ALT repeated or abnormal relationship between patients with hepatocellular carcinoma, hepatitis with jaundice occurred slowly, only Austria insist on doing, will have the answer.