The etiology of psoriasis is complex and unclear. In recent years, many scholars believe that it may be related to genetic, infection, metab
The etiology of psoriasis is complex and unclear. In recent years, many scholars believe that it may be related to genetic, infection, metabolic disorders, immune dysfunction, endocrine disorders. Although psoriasis experts around the world for many years, but still can not cure.
According to the clinical observation, the incidence of psoriasis is related to the following factors:
Genetic factors. It is believed that the disease is controlled by many genes, and it is also influenced by other factors. Two, infection factors. Some people think that it is caused by viral infection, although it has been found in the epidermis of the nucleus of the spinal cord eosinophilic inclusion body, but so far the virus culture failed. Streptococcal infection may be an important predisposing factor for the disease, because of acute guttate psoriasis rash often before acute tonsillitis or upper respiratory tract infection.
Three, metabolic disorders. The serum lipid, cholesterol, globulin, glucose, uric acid, potassium and so on were reported to increase, but the folic acid content decreased, but all of them failed to make a positive conclusion. It was also reported that polyamines and arachidonic acid increased in the skin lesions of four.
Four, immune dysfunction. Some patients with low immune function; serum IgG, IgA and IgE have increased; some of the patients in the presence of anti IgG antibodies; some people use immunofluorescence technique to measure the epidermal layer in patients with anti keratin antibodies.
Five, mental factors. Mental trauma and emotional stress and overwork can induce the disease or aggravate the disease. Six, other factors. Most of the patients in remission or recurrence and aggravation of the summer, but natural subsidise, long season regularity disappeared. There are some women in the menstrual period before and after aggravating, pregnancy rash subsided, recurrence after delivery. Chloroquine, lithium carbonate and beta adrenergic blockers can make the disease worse.
It is generally believed that the pathogenesis of psoriasis must have two factors, one is the presence of psoriasis susceptibility genes. Two is to encounter adverse external stimuli.
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