Propranolol (Inderal): the effect of medicine in infantile hemangioma

A used 50 years of anti high blood - propranolol (propranolol, propranolol), was found to have a new magical therapeutic effect, namely prop


A used 50 years of anti high blood - propranolol (propranolol, propranolol), was found to have a new magical therapeutic effect, namely propranolol in the treatment of hemangioma is effective, and the treatment will not occur at present the most commonly used therapy -- many adverse reactions of hormone therapy.

Neonatal hemangioma is a very unsightly and disfiguring diseases, the incidence rate of 10% births in the United States in high. Hemangioma usually occurs several weeks after birth, reaching peak at 3 months. 75% of hemangioma with the baby will gradually shrink, mostly in preschool disappear. However, some severe hemangiomas can persist, and even affect the baby's breathing and vision, as well as the oppression of adjacent vital organs. Therefore, hemangiomas need treatment to accelerate the process of narrowing.

The use of propranolol in the treatment of hemangioma of the report, the earliest found in France Bordeaux children's Hospital L aut -Labr Ze report, they are using propranolol in the treatment of 1 cases of cardiomyopathy and another example of the increase in cardiac output in sick infants (all patients hemangioma), accident and was surprised to find that their hemangioma atrophy small. Then, they use propranolol treatment in 9 cases of hemangioma in infants, the results achieved the same success. This news caused great repercussions in the pediatric dermatologists, many physicians began experimenting with propranolol in the treatment of hemangioma. However, there are a number of physicians who are cautious about this treatment, and they look forward to a formal clinical trial to test the efficacy and safety of this approach.

Johns Hopkins University validation

This news caused the Johns Hopkins University children's Medical Center Department of Dermatology director Bernard A. Cohen, he believes that this treatment is very reasonable, so I decided to study was carried out to verify the safety and efficacy of beta blockers in the treatment of diseases in Department of dermatology.

The most commonly used methods for clinical treatment of hemangioma for hormone therapy, such as the use of prednisone, and the treatment of adverse reactions including elevated blood glucose, sodium and water retention, osteoporosis, infection, and is not conducive to the growth of the baby. Cohen said that they do not like the use of hormone therapy, often in the absence of other choices. So far, Cohen and colleagues have at Johns Hopki children's medical center using propranolol in the treatment of 20 cases of hemangioma in infants, and experts and the Department of Cardiology, monitoring of adverse reactions in the treatment received 2 days before the infant is possible (such as hypotension or low blood sugar), but so far has not observed any adverse reaction occurrence. According to Cohen, an excellent effect of propranolol, sometimes in the first time you can see the risk of infant hemangioma becomes dark, usually see the treatment effect in 24 hours. "When my dermatologist has been 25 years, but this is the treatment of" I saw the fastest onset, Professor Cohen said. It is reported that L aut -Labr Ze and his colleagues are applying for beta blocker therapy in neonatal (baby) capillary hemangioma of the patent. But the specific mechanism of propranolol in the treatment of hemangioma is not clear. The clinical application of propranolol has 50 years of history, the slight side effects. At present, the Chinese Medical Association has recommended it as a first-line drug for clinical treatment of hemangioma. Maternal and child cosmetology department application of propranolol in treating infantile hemangiomas since last year, most of the patients responded well to it, and no obvious side effects.

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