What is hyperparathyroidism?Abnormality of calcium and phosphorus metabolism caused by parathyroid hormone secretion of parathyroid hormone
What is hyperparathyroidism?
Abnormality of calcium and phosphorus metabolism caused by parathyroid hormone secretion of parathyroid hormone (PTH). Phpt. The main manifestations of skeletal changes, urinary calculi, hypercalcemia and hypophosphatemia. Cause of secondary hyperparathyroidism is various cause hypocalcemia caused by long-term stimulation of parathyroid gland, such as chronic renal failure, lack of vitamin D, vitamin D malabsorption and generation disorder caused by intestinal, liver and kidney disease. Pregnant lactating women on calcium demand but not the corresponding supplement, also appears hypocalcemia all can cause excessive secretion of parathyroid hyperplasia, PTH. Primary hyperparathyroidism of unknown etiology. It was reported that the incidence rate of benign or malignant parathyroid and thyroid tumors after radiotherapy was 11 to 25%. Some families in the father, mother, brother and sister are suffering from the disease. Therefore, the relationship between the occurrence of the disease and the radiation exposure and genetic relationship remains to be further studied.
How to find hyperparathyroidism?
Parathyroid hyperfunction usually manifested as fatigue, no strength, intelligence and personality changes, memory loss, irritability, irritability, insomnia and mood swings, with obvious mental symptoms, severe cases coma. There may be loss of appetite, nausea, vomiting and constipation. If the above symptoms should be promptly to the hospital.
The concentration of serum PTH is a direct and sensitive index for the diagnosis of this disease, the determination of PTH N-terminal and C-terminal segment, and several kinds of radioimmunoassay, the diagnosis of hyperparathyroidism and surgery with this index is consistent with the rate of about 90%. The severity of blood and increased the level of PTH and serum calcium concentration, tumor size and severity in parallel. But in secondary hyperparathyroidism, PTH can also increase the blood PTH and serum calcium, urinary calcium, X ray examination and clinical manifestations of the combined analysis is helpful for differential diagnosis of both. Cyclic adenosine monophosphate (cAMP) can be increased. Bone mineral density decreased. X ray characteristic changes in bone in the head, hands firmly, teeth and pelvis. There are urinary stones and renal calcification.
Treatment of hyperparathyroidism
If no symptoms of mild hypercalcemia, should follow the observation, generally do not need special treatment, or drug treatment or surgical treatment. If the following conditions must surgical treatment: calcium is higher than 12mg%. The blood PTH was 2 times higher than the normal value. The X - ray manifestations of bone disease. The activity of urinary calculi. The decline in renal function. The serious mental disease, ulcer disease, pancreatitis, hypertension. All tumors of the parathyroid glands should be explored, whether tumor or hyperplasia. If the adenoma should be removed. For adenocarcinoma, radical surgery should be done. We have many more cases of patients with fracture and recurrent renal calculi, is actually due to primary hyperparathyroidism, a minimally invasive parathyroid surgery to heal and relieve pain.
If parathyroid hyperplasia especially secondary hyperparathyroidism secondary to renal failure, uremia, with 3.5 glands, 4 glands can also be removed, and then take a small part of parathyroid autotransplantation, buried in the forearm muscles.
Video-assisted parathyroid surgery, similar with endoscope assisted thyroid surgery, is more beautiful, more safe and reliable, is the better choice for treatment of parathyroid hyperfunction.