Causes of eosinophilia

Check the blood eosinophil (EOS) absolute value > 0.5 * 109/L is called eosinophilia.The majority of eosinophilia is due to a variety of

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Check the blood eosinophil (EOS) absolute value > 0.5 * 109/L is called eosinophilia.

The majority of eosinophilia is due to a variety of physical diseases secondary to increased reactivity, common causes include:

1 infections (such as parasitic infections, tuberculosis and Chlamydia infection, etc.);

2 drugs (anticonvulsants, antibiotics, sulfonamides and antirheumatic drugs, etc.);

3 allergic reactions (asthma, allergic rhinitis and urticaria, etc.);

4 connective tissue diseases (rheumatoid arthritis, scleroderma and polyarteritis nodosa etc.);

5 neoplastic diseases (such as AML-M4EO and CML, lymphoma, solid tumors, metastatic carcinoma, etc.);

6 other rare causes such as endocrine disorders, Addison's disease and pituitary insufficiency, GVHD and immunodeficiency diseases, etc..

EOS secondary to these diseases is generally mild to moderate. Doctors need to ask for details of the history, including the recent history of tourism, to check whether the presence of these diseases.

If there is no clear secondary factors, consider primary or clonal eosinophilia, you need to blood specialist. In the past, it is called HES syndrome, which is known as EOS syndrome, which is caused by unknown secondary factors. As a result of the understanding of HES in recent years, the HES of non secondary factors are divided into the following categories:

1.PDGFR -, PDGFR -, or FGFRl - positive, myeloid or lymphoid tumors associated with eosinophilia are classified into one class of 2008WHO myeloid tumors. FIP1L1/PDGFRA fusion gene positive, or chromosome 4q12,5q33, or 8p11 ectopic.

2 chronic eosinophilic leukemia (CEL):EOS> 1.5 * 109/L, peripheral Blastsand > 2%, > (5% bone marrow blasts; but < 20%) or a change of clonal genetics, but no bcr-abl fusion gene, PDGFR alpha, PDGFR beta or fgfrl rearrangement.

3 lymphocyte variant: the presence of abnormal phenotype of clonal T cells, but does not meet the diagnosis of leukemia or lymphoma, the production of Th2 cytokines (such as IL-5) lead to increased EOS, and other types may overlap.

4 idiopathic HES (IHES): the previously defined EOS in peripheral blood for 6 months is more than 1.5X109/L, currently only two EOS were more than 1.5X109/L, more emphasis on the exclusion of secondary factors and cell tropism of the cloned acid disease.

 

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