Does magnesium in the diet affect the formation of urinary stones?Clinical study found that some patients with urinary stones in the urine o
Does magnesium in the diet affect the formation of urinary stones?
Clinical study found that some patients with urinary stones in the urine of magnesium levels are low. There was also no decrease in urinary magnesium excretion in patients with calcium oxalate stones, but the ratio of magnesium to calcium in urine and the ratio of magnesium to oxalic acid decreased. Oral magnesium can reduce the level of uric acid and calcium oxalate in the urine of patients with urinary calculi, and reduce the recurrence rate of urinary calculi. It is also believed that only a large amount of magnesium has a strong inhibitory effect on the formation of calcium oxalate crystals.
The mechanism by which magnesium reduces the risk of urinary calculi formation includes: magnesium can combine with oxalic acid in urine to produce magnesium oxalate complex with higher solubility than calcium oxalate. Magnesium can inhibit the formation of calcium oxalate combined with a high stability of calcium oxalate monohydrate, and promote their formation of poor stability of two calcium oxalate dihydrate. The magnesium decreased urinary calcium oxalate saturation, increase urinary citrate excretion. For patients of Magnesium Oxide or magnesium citrate magnesium deficiency, they can make magnesium and citrate excretion in urine increased, helps to reduce the recurrence rate of urinary calculi. However, it is not clear whether magnesium supplementation can be used to achieve an appropriate level of urinary magnesium through diet, so as to prevent the formation of urinary calculi.
Does the potassium in the diet affect the formation of urinary stones?
Epidemiological investigation showed that the decrease of potassium intake can increase the risk of urinary stone formation. However, there was no significant difference in the intake of potassium in the diet of patients with urinary calculi compared with the control group. Potassium can reduce the excretion of urinary calcium, urinary stones in patients with urinary sodium / potassium ratio increased. Potassium carbonate and potassium citrate supplementation can reduce urinary calcium excretion, limit their intake of potassium increased urinary calcium excretion. The mechanism by which potassium reduces urinary calcium excretion may be related to the transient diuresis effect of potassium gluconate, as well as to the increase of renal tubular reabsorption of calcium and phosphate. Phosphate can inhibit the synthesis of 1,25- (OH) 2D3, reduce the absorption of intestinal calcium, urinary calcium excretion also decreased. In addition, the alkaline substance rich in potassium foods also contain more, which can promote the excretion of urine citrate.