What is the effect of fat in the diet on the formation of urinary stones?

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(1) there is no consistent conclusion about the influence of the fat content in the unsaturated fatty acid diet on the incidence of urolithi

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(1) there is no consistent conclusion about the influence of the fat content in the unsaturated fatty acid diet on the incidence of urolithiasis. In Japan, the rise in the incidence of kidney stones in the population is consistent with the increase in daily consumption of fat and oil. It has been reported that a greater intake of unsaturated fatty acids is associated with kidney stones more closely than protein and sugar consumption. In the small intestine, the free fatty acid and calcium ion binding, inhibit the calcium and oxalic acid combined with the formation of calcium oxalate is not easy to absorb, thereby increasing the number of free intestinal lumen of oxalic acid, promote the intestinal absorption of oxalic acid. Excessive absorption of oxalic acid from the kidney, increasing the risk of calcium oxalate stone formation.

There is evidence that a diet rich in twenty carbon and five acid reduces the risk of urinary stone formation. The Japanese coastal residents and incidence of urinary calculi rate is very low, and their daily diet consumption of a large number of fish oil on. The active ingredient of fish oil is polyunsaturated fatty acids, of which EPA is the main component. At present, it has been found that the excretion of urinary calcium is closely related to the activity of prostaglandin, fish oil can inhibit the synthesis of prostaglandins, so that the elimination of urinary calcium excretion, thereby inhibiting the formation of urinary stones. Urinary fibrinolytic activity is an important protective factor in the pathogenesis of renal calculi, and its activity is related to the fibrinolytic activity of the blood circulation. Fish oil can increase the fibrinolytic activity of the blood circulation, thus indirectly affecting the fibrinolytic activity in urine. In addition, fish oil can reduce the excretion of calcium in the urine of the experimental rats and prevent the formation of calcium phosphate in the kidney. The clinical use of fish oil in the treatment of hypercalciuria recurrent urinary calculi patients, can make their 24h urinary calcium, magnesium and urinary citrate excretion decreased, but urinary oxalate and fibrinolytic activity did not change significantly.

(2) cholesterol has been known to contain cholesterol in various types of urinary stones, and its content is higher than that of general trace elements. Therefore, the relationship between abnormal cholesterol metabolism and urinary calculi is gradually attracting people's attention. In vitro studies have found that 90% of the cholesterol in the liquid containing crystals (calcium oxalate, calcium phosphate and uric acid). Further studies showed that cholesterol could promote the nucleation of two calcium oxalate monohydrate. Animal experiments also confirmed that high cholesterol diet can induce the formation of calcium phosphate stones in the kidney of rats.

 

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