Most patients have a profound understanding of myasthenia gravis. Treatment of myasthenia gravis, depending on the patient's condition, need
Most patients have a profound understanding of myasthenia gravis. Treatment of myasthenia gravis, depending on the patient's condition, need to decide whether to remove the thymus. But is it possible for everyone to realize that what is the role of the thymus in the treatment of myasthenia gravis?
Thymus is the cause of myasthenia gravis. Thymus in people born before and after the main body to help improve the immune system, especially the cultivation and release of T- lymphocytes and the spleen to settle the body in two secondary lymphoid organs, lymph node. After puberty is thymus gradually atrophic, functional degradation. The thymus of patients with myasthenia gravis will not degenerate, but has many kinds of harmful antibodies, especially acetylcholine receptor antibody, directly closed or destroys the nerve muscle synapses on acetylcholine receptors, prevent motor nerve signal transmission, and with the extension of the stage of the disease and the damage becomes irreversible, and most of the antibody in the thymus in the synthesis of acetylcholine receptor; participate in the destruction of T lymphocytes in the thymus of sensitization. At the same time, the initial antigen of autoimmune reaction can cause the MG (i.e. muscle cells) are also present in the thymus. Therefore, the goal of various therapeutic methods is mainly directed against antibodies, lymphocytes and thymus tissue. Surgical removal of the thymus can avoid the irreversible damage of acetylcholine receptors at the neuromuscular junction, which is the only effective means to block the pathological process, and is the first choice for the treatment of myasthenia gravis.
The theoretical basis of thymectomy for myasthenia gravis
1, get rid of the germinal center of thymus antibody producing cells;
2, get rid of with antigen stimulation of myoid cells and thymic tumor cells;
3, remove the memory T cells and auxiliary T cells to produce and mature base, these two kinds of T lymphocytes play an important role in helping and inducing B lymphocytes to produce autoantibodies;
4, cut off the source of thymosin, releasing the inhibitory effect of thymosin on acetylcholine synthesis and release;
5, to avoid a large number of permanent irreversible damage to acetylcholine receptors at the neuromuscular junction.