Relationship between esophageal cancer and genetic factors

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According to the survey found that the pathogenic factors of cancer has been a certain relationship with the genetic, many families of patie

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According to the survey found that the pathogenic factors of cancer has been a certain relationship with the genetic, many families of patients will show a higher incidence than the average person. Here is a brief introduction of esophageal cancer.

The incidence of esophageal cancer has obvious familial aggregation, which is related to the susceptibility of the population and the environment. In the high incidence area of esophageal cancer, 3 or more generations of patients with esophageal cancer appeared in the family of 3. In China, Shanxi, Shandong, Henan Province, the survey found a positive family history of esophageal cancer patients accounted for about 1/4 to 1/2, in a high risk area of positive family history in proportion to the second highest paternal, maternal, minimum collateral. Immigrants from low incidence areas of high incidence areas, even after more than a hundred years, the incidence is relatively high. Living environment also affects the incidence of esophageal cancer, has been found in the high incidence area with the family living together for more than 20 years of esophageal cancer patients accounted for 1/2. Genetic and environmental factors on the incidence of esophageal cancer is likely to change at the molecular level have been found in some high incidence of cancer in the family, often have tumor suppressor genes, such as P53 point mutation or loss of heterozygosity in this population, such as acquired another factor causing allele the mutation will cause abnormal expression of oncogenes and tumor formation. In recent years, the data show that esophageal cancer patients in the presence of oncogenes and tumor suppressor gene mutations. One

 

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