Brief introduction of FOLFOX regimen chemotherapy

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At present, the common chemotherapy regimen is FOLFOX, and there are 2 different methods of administration:1, mFOLFOX6 solution time: Asha L

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At present, the common chemotherapy regimen is FOLFOX, and there are 2 different methods of administration:

1, mFOLFOX6 solution time: Asha Leigh Per: intravenous infusion 2 hours, first days;

CF: 2 hour intravenous infusion for first days;

5-Fu: continuous intravenous infusion 44-46 hours

3-4 weeks after surgery to evaluate the patient's condition after the first chemotherapy, if there is no obvious discomfort, then according to the program of regular chemotherapy. Repeat 1 times every 2 weeks, a total of 12 times chemotherapy.

2, FOLFOX solution time: Asha Leigh Per: intravenous infusion 2 hours, first days;

CF: 2 hour intravenous infusion, first to 5 days;

5-Fu: intravenous infusion 2 hours, from first to 5 days;

3~4 weeks after surgery to evaluate the patient's condition after the first chemotherapy, if there is no obvious discomfort, then according to the program of regular chemotherapy. Repeat 1 times every 4 weeks, a total of 6 times chemotherapy.

In 3, the hospital discharge procedures:

The patient was given a start date for the first chemotherapy, and 2 or 4 weeks later, the initial estimate of the start date of the next chemotherapy. 4 days before this date, the blood routine test, hospital appointments. Ward doctors will try to arrange for you to receive chemotherapy. On the day after admission, the patient should be hospitalized for fasting. Check again after admission, blood and liver function, if the results are normal, in the hospital that afternoon feasible chemotherapy. First days of chemotherapy should strictly abide by the principle of hospitalization, shall not leave home. After first days of intravenous chemotherapy after treatment for chemotherapy patients will last 44-46 hours after 5-Fu pump, liquid pump completely finished, should review the blood and liver and kidney function, according to the results of further processing. Select the FOLFOX4 program, need to be hospitalized for 5 days, the review of blood and liver and kidney function after fifth days drip, if the results are normal, on the same day or second days of discharge. If the admission day blood test results significantly abnormal, such as white blood cells decreased or elevated transaminase, need for treatment or treatment of liver or white. After the treatment of white blood cells and liver function, the results returned to normal after the start of this chemotherapy.

4, outside the hospital notes:

Due to bone marrow suppression, gastrointestinal reactions, neurotoxicity of oxaliplatin adverse reaction report, the adverse reaction of 5-Fu for gastrointestinal reaction, so patients with chemotherapy should pay close attention to condition changes outside the hospital, if abnormal, timely medical treatment.

1) bone marrow suppression: patients should pay close attention to the fluctuation of white blood cells in the interval of chemotherapy. Every day 3~4 recommends that patients after discharge review of blood, if found white blood cells or neutrophils is less than 4.0X109/L, less than 1.5X109/L, to the leukogenic treatment.

2 gastrointestinal reaction: the patient may have nausea, vomiting and other gastrointestinal reactions during chemotherapy, so the chemotherapy interval to see the patient diet, light, in order to prevent nausea, vomiting and other symptoms. If severe vomiting should be promptly treated with rehydration therapy.

3) neurotoxicity: the main manifestation of extremity sensory disturbance or / and paresthesia. With or without cramps, usually the symptoms of cold stimulation. It is reported that the incidence of neurotoxicity caused by Asha Leigh Per 85-95%. During the period of treatment, the symptoms usually decrease, but with the increase of the treatment period, the symptoms will gradually increase. If the symptoms are severe, and the duration is longer, should be reported in the next chemotherapy. The doctor will according to the specific circumstances of patients, decided to suspend the use of oxaliplatin or reduction.

 

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