Febrile seizures, epilepsy, and vaccination (Reprint)

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Vaccination is a common concern among doctors, parents, health and epidemic prevention departments. Vaccination really induced epilepsy? Hea

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Vaccination is a common concern among doctors, parents, health and epidemic prevention departments. Vaccination really induced epilepsy? Heat shock or epilepsy children whether vaccination? This article may be answering questions for everyone.

Febrile seizures, epilepsy and vaccination

Guo Hu, Chen Jing. Journal of epilepsy and electrophysiology, 2015, (5) (in Chinese), 24

Vaccination is an effective measure for the prevention of disease, people focus on vaccination is effective in preventing the disease from the vaccine is transformed into vaccine reactions, especially the adverse reactions in the nervous system,.

1 are there any contraindications to vaccination in children with a history of febrile seizures? Is it necessary to avoid a vaccine that is significantly associated with the risk of febrile seizures?

In conclusion, vaccination may increase the risk of febrile seizures. DPT vaccine inoculation significantly increased the risk of febrile seizures, the reasons and the increased risk of this type of vaccine with high fever and side effects, the relationship between dose and age is not clear. Measles rubella and mumps triple vaccination significantly increased risk of febrile seizures, the reasons and the increased risk of this type of vaccine with high fever and side effects, especially in vaccination within 2 weeks after immunization, the need for further research after the first febrile convulsion after repeated febrile convulsion and (or) incidence epilepsy. Some vaccines, especially DPT vaccine (especially the whole cell vaccine) and measles vaccine (especially with varicella) can cause fever and febrile convulsion possible; with or without a history of febrile seizures in children after vaccination febrile seizures had similar incidence of febrile convulsion; febrile seizures after vaccination is not compared with other causes of fever caused by frequent; vaccine induced febrile convulsion after seizures than non vaccine induced febrile convulsion children. Suggest no taboo to have a history of febrile seizures in children vaccination; do not prevent the parents give their children vaccinated, but parents should be informed of some vaccines and febrile seizures and subsequent seizures, especially the history of febrile seizure and (or) children less than 6 years old.

2 are there any contraindications to vaccination for children with epilepsy? Is there any need to avoid any vaccine associated with epilepsy?

The vaccine does not cause seizures and epilepsy; adverse reactions after the vaccination of children with epilepsy have increased, children with epilepsy without vaccination contraindication; after vaccination with?? risk does not prevent parents by vaccination.

3 are there any contraindications to vaccination for children with epileptic encephalopathy? Is there any need to avoid any vaccine related to epileptic encephalopathy?

The classic infantile spasms disease at the age of 6 months, and routine vaccination age, time between Goodman in 1998 and speculation of infantile spasms of DPT vaccine, the study found no vaccination increased the total number of cases of infantile spasms, failed to confirm the correlation between the two, only that vaccination reduced seizure interval. On 2008 Guggenheim found that after the incident did not occur after encephalopathy infantile spasms, infantile spasms and refuted the onset of vaccination in close temporal association. Doose - Gataut syndrome and Lennox syndrome often occurs in older children, so there is little relationship between vaccination and literature, only isolated and doubtful case report. Berkovic retrospective study of 14 suspected vaccine encephalopathy children first seizure after vaccination of 72h in 11 cases of SCN1A mutations, the final diagnosis of Dravet syndrome, the remaining 3 cases while SCN1A mutation negative, still can not rule out other mutations, the authors explain the actual vaccine encephalopathy genes. In 2010, Mcintosh in 40 cases were retrospectively analyzed the clinical characteristics of Dravet syndrome and SCN1A mutations, concluded that vaccination may trigger an earlier onset of Dravet syndrome, because these children are SCN1A mutations, Dravet syndrome occurs sooner or later, probably due to vaccination induced fever triggered Dravet syndrome, the primary factors of vaccination is not a disease the. 2011 - Tro Baumann retrospective analysis of 70 cases with vaccine related seizures in Dravet syndrome patients, 27% seizures after vaccination, vaccine related events in these patients was first reported in 58% is that vaccine related seizures, seizures are common in Dravet syndrome, which may be a significant feature.

Vaccination and the first year after birth onset epileptic encephalopathy (Dravet syndrome, West syndrome) no causal relationship between vaccination may trigger the early onset of epilepsy?? syndrome; vaccination and vaccination increased risk of encephalopathy no correlation. The epileptic encephalopathy (Dravet syndrome, West syndrome) children without vaccination contraindications, vaccination did not stop on the basis of such children, but should inform the parents of children with the risk of vaccination with the prophylactic use of antiepileptic drugs may help. For the fever and the presence of SCN1A mutations in patients before and after treatment of early vaccination more active prevention within a short period of time (or) benzene two nitrogen drugs, combined with antiepileptic drug treatment?? bad progress may prevent and occurrence of vaccine associated seizures and disease.

In short, DPT vaccine and measles rubella and mumps vaccine increased the risk of febrile seizures, fever and side effects may be related to vaccine; vaccination does not cause seizures and epilepsy after vaccination, the so-called epileptic encephalopathy may be related to gene mutation, vaccination may trigger the disease early onset so for; suffered or are suffering from such diseases in children are not vaccinated with the taboo, but need to inform the parents of vaccination may increase the risk of developing the disease, for Dravet syndrome and SCN1A mutations exist before and after vaccination of children within a short period of time to prevent fever and anticonvulsant treatment may have some help.

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