Discovery and preliminary study of GP73GP73 is a transmembrane protein present in the Golgi apparatus. In 2000, the Kladney study showed tha
Discovery and preliminary study of GP73
GP73 is a transmembrane protein present in the Golgi apparatus. In 2000, the Kladney study showed that GP73 was mainly expressed in bile duct epithelial cells in normal human liver tissue, but the expression of hepatocytes was very little or no expression. The expression of GP73 can be increased by the infection of hepatocytes. Further study indicates whether by viruses (HBV and HCV) caused by infection or by non viral causes (alcoholic liver disease and autoimmune hepatitis) in patients with liver disease caused by elevated levels of GP73, to a certain extent. The expression of GP73 may have different mechanisms, one is triggered by acute liver injury, and the other is in the process of chronic liver disease. Maitra suggests that GP73 is highly expressed in both acute and chronic liver diseases, suggesting that this protein may not be helpful in the diagnosis of liver disease. Until 2005 Block et al found that serum GP73 levels were significantly elevated in HCC patients. In one study, serum GP73 levels were significantly higher in 144 patients with liver cancer than in patients with cirrhosis. The sensitivity and specificity of GP73 in diagnosis of liver cancer was 69% and specificity was 75%. For early cancer (T1: single nodules, the diameter of < 2 cm and T2: a single nodule diameter between 2cm~5cm or less than three nodules, each with a diameter of < 3 cm) in the diagnosis, the sensitivity of GP73 (62%) was significantly higher than AFP (25%). In addition, GP73 levels were significantly higher in 57% (32/56) of HCC patients with AFP levels below those of ng/mL (). Thus, the serum level of GP73 in patients with liver cancer was significantly increased, and for the early diagnosis of liver cancer, GP73 may be better than AFP. Cassandra therefore suggests that GP73 may be a better marker for the diagnosis of HCC, especially in early hcc.