Prolongation of overall survival in advanced lung cancer

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    by the Bellani (Belani) clinical efficacy and safety, pemetrexed or placebo immediately given clinical trials of international

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    by the Bellani (Belani) clinical efficacy and safety, pemetrexed or placebo immediately given clinical trials of international multi center led the comparison of advanced lung cancer after first-line chemotherapy showed that pemetrexed maintenance therapy in patients with overall survival of 13.4 months, while the placebo group survival for 10.6 months (P=0.012). This means that 21% of the risk of death can be reduced by the use of Sai as a maintenance therapy. As pemetrexed in the first-line treatment of the study as well as in the maintenance treatment of lung adenocarcinoma and its effect is the best, the median survival was 15.5 months (P=0.002) but for the maintenance treatment of lung squamous cell carcinoma has no difference with placebo, the median survival was only 9.9 months (P=0.67).

    it is worth mentioning that pemetrexed maintenance therapy rarely serious side effects, 3/4 neutropenia and anemia incidence rate of only 3%, the fatigue occurrence rate is 5%, is completely resistant to toxic chemotherapy drugs a patient.

 

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