Epilepsy patients taking antiepileptic drugs, the doctor often to test the blood concentration, and adjust the dose according to the plasma
Epilepsy patients taking antiepileptic drugs, the doctor often to test the blood concentration, and adjust the dose according to the plasma concentration, then what is the concentration of antiepileptic drugs? Why do you need to do this?
The plasma concentration of antiepileptic drugs is the content of drugs in the plasma, and the clinical antiepileptic effect is the concentration of free drug. Steady state blood concentration is defined as the concentration of blood when the amount of drug absorbed is equal to that of the drug after repeated dosing, quantitative and regular. The time to reach steady-state concentration of the drug is generally about 5 half life of the drug. If in a certain period of time the total amount of medication unchanged, changing the number of drugs generally does not affect the steady-state speed and concentration. However, reducing the number of times the drug concentration fluctuations increased. The effective blood concentration refers to the complete seizure control or most antiepileptic drugs, blood concentration and clinical and no poisoning symptoms or no unacceptable toxicity, and reach steady state plasma concentration range of therapeutic effect. Clinicians help to adjust the dose according to the concentration and guide the treatment.