Clinical study on regulating NO/ET and MMP/TIMP imbalance in diabetic nephropathy with the traditional Chinese Medicine

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To observe the clinical curative effect of the treatment of the solid drink clearance of diabetic nephropathy, and on nitric oxide (NO) / se

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To observe the clinical curative effect of the treatment of the solid drink clearance of diabetic nephropathy, and on nitric oxide (NO) / serum endothelin (ET), serum matrix metalloproteinase (MMP) / matrix metalloproteinase inhibitor (TIMP) imbalance effect. Methods: 100 cases of diabetic nephropathy were randomly divided into treatment group and control group of the 50 cases, the control group received routine treatment, the treatment group in the control group treated with the clearance of wear solid drink. To observe the clinical efficacy, changes of TCM syndrome score, life quality score and serum ET-1, NO, MMP-9 and TIMP-1 levels before and after treatment. Results: the total effective rate of treatment group was 88%. The control group was 74%, 2 groups had significant difference (P < 0.05) comparing integral and survival quality of TCM syndrome score after treatment in group.2, there were significant differences (P < 0.05). Compared before and after the treatment, the difference was significant. Yi (P < 0.01) in.2 group, serum ET-1, NO MMP-9 and TIMP-1 levels after treatment, there was significant or very significant difference (P < 0.01, P < 0.05) in.2 group compared before and after the treatment, the differences were very significant (P < 0.01). Conclusion: the customs clearance the clinical symptoms and biochemical indexes of decoction can improve the patients, improve the quality of life of patients

Published in: "new Chinese medicine" 2011 43 volume 05

American Chemical Abstracts

Chinese core journal (the core journals included)

 

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