What is the relationship between Helicobacter pylori infection and chronic gastritis?

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The results of epidemiological investigation showed that the relationship between Helicobacter pylori infection and chronic gastritis was cl

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The results of epidemiological investigation showed that the relationship between Helicobacter pylori infection and chronic gastritis was clear, and it was the main pathogenic factor of chronic gastritis. The detection rate of Helicobacter pylori in gastric mucosa biopsy specimens of patients with chronic gastritis was as high as 60~80%, and the detection rate of patients with chronic active gastritis was higher, up to 90~100%. A large number of Annie Yi data show that the rate and the incidence of chronic gastritis is roughly parallel relationship between Helicobacter pylori infection and Helicobacter pylori associated gastritis patients after effective antibiotic therapy for eradication of Helicobacter pylori, the clinical symptoms and pathological changes also will be improved. Human health volunteers test also confirmed that oral Helicobacter pylori induced gastric mucosal inflammatory changes, and upper abdominal pain, nausea and vomiting symptoms.

The mechanism of Helicobacter pylori infection on gastric mucosal injury may be related to the following factors:

1 pathogenic factors of Helicobacter pylori on gastric mucosa damage. Vacuolating toxin produced by Helicobacter pylori (Vac A) and cytotoxin associated protein (CagA) can cause gastric mucosal barrier injury; multiple enzyme producing Helicobacter pylori, such as urease, protease, lipase, phospholipase A viscosity, lipopolysaccharide and hemolysin can damage the gastric mucosal barrier, mediated inflammatory reaction.

2 Helicobacter pylori infection can cause a variety of invasive cells and inflammatory mediators release, resulting in gastric mucosal damage.

3 Helicobacter pylori can induce humoral and cellular immune responses, and stimulate the immune cells to produce TNF-a. IL-1, IL-8 and so on, these cytokines and subsequent inflammatory reaction may be an important pathophysiological factor causing mucosal damage.

4 autoimmune reaction: some of the Helicobacter pylori infection can be detected in the anti gastric epithelium, G cells, parietal cells and H+ - K+ATP enzymes and other components of the gastric mucosal cell autoantibodies.

It can be seen that the role of Helicobacter pylori through a variety of pathogenic factors, resulting in impaired gastric mucosal barrier, mucosal cell degeneration and necrosis, a large number of inflammatory cells infiltration, resulting in chronic gastritis.

This article reprinted from http://user.qzone.qq.com/345040900/blog/1417511183

 

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