How does Helicobacter pylori cause gastric mucosal damage?

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Helicobacter pylori (Hp) can be divided into four categories according to pathogenic factors and their characteristics, which can be divided

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Helicobacter pylori (Hp) can be divided into four categories according to pathogenic factors and their characteristics, which can be divided into Hp categories:

(1) pathogenic factors associated with Hp colonization

(2) the main pathogenic factor of the injured mucosa

(3) pathogenic factors associated with inflammation and immune damage

(4) other pathogenic factors.

Example of pathogenic factor:

(1): in many of the pathogenic factors of urease, Hp produced urease play an important role in the pathogenesis of Hp. Hp urease producing, urease hydrolysis of urea, ammonia release (NH3). Ammonia can directly damage the gastric mucosa, but the protection of Hp in gastric mucosa of survival, Hp itself in the "ammonia cloud" package of around against gastric acid and pepsin invasion, make its survival in a low pH environment.

(2) cytotoxin cytotoxin (vaculating cytotoxin A, Vac A)

(3) cytotoxin associated protein (protein Cytotoxinassociated, CagA)

(4) Hp, lipopolysaccharide, protease, lipase, phospholipase A2.

The common pathogenic factors, cause local inflammation and immune reaction of gastric mucosa, gastric mucosa inflammation and immune injury suffered, and the damage of gastric mucosa is more vulnerable to the invasion of gastric acid and pepsin.

Hp is G - bacilli, S or L shape, long 1.5~5.0um, wide 0.3~10um0.3~1.0um, under the electron microscope, the surface of the cell is smooth, one end of the 2~6 band with a little flagellum, the top of the flagellum is spherical, Hp depends on the flagellum movement. Because of the characteristics of adhesion colonization in gastric mucosa and adjacent surface epithelium and reproduction.

The pathogenic mechanism of Hp is very complex, the Hp virulence factors on gastric mucosal damage and harm to the human body including the bacteria itself in gastric mucosal colonization caused by direct injury, injury caused by a toxin produced by bacteria, bacterial host of strong immune response to bacterial infection after injury, and cause all the consequences of gastrin and somatostatin secretion disorders caused by abnormal gastric acid secretion caused by.

Generally speaking, the Hp infection factor for colonization factor and virulence factor, which is the first condition of colonization factor of Hp infection, play a role in virulence factor Hp after transplanting, cause gastric mucosal injury, disease.

The reason Hp can be planted in gastric mucosa, mainly because Hp itself has a power device, adhesion, toxic enzymes and various toxins to help Hp growth in gastric mucosa and reproduction, pathogenic factor of Hp help Hp run amuck in gastric mucosal damage, the structure and function of normal gastric mucosa, produce corresponding disease.

This article reprinted from http://user.qzone.qq.com/345040900/blog/1417501148

 

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