(the following is an excerpt from our science and technology dynamic Edition) in 2000, Douglas Hanahan and Robert A. Weinberg in "Cell" writ
(the following is an excerpt from our science and technology dynamic Edition) in 2000, Douglas Hanahan and Robert A. Weinberg in "Cell" written on the topic is: The Hallmarks of Cancer review, explains 6 basic characteristics, namely: the tumor cell growth signal (Self-Sufficiency in Growth Signals.); not sensitive to anti growth signals (Insensitivity to Antigrowth Signals (Evading); apoptosis; Apoptosis) to avoid replication potential (Limitless Replicative Potential); continuous angiogenesis (Sustained Angiogenesis); tissue invasion and metastasis (Tissue Invasion and Metastasis). This classic review of oncology was quickly cited by life science workers and textbooks, and has been cited 10643 times (as of today, with reference to the Google scholar search).
Today (March 4, 2011), they published in the Cell on the review of the updated version, entitled: Hallmarks of The Cancer: Next Generation. The review of 29 pages, the hot spot and the progress in recent 10 years in oncology (such as autophagy, tumor stem cells, tumor microenvironment, etc.) and 6 characteristics of past amplified to 10 characters, 4 new features for avoiding immune destruction (Avoiding Immune Destruction); promote tumor inflammation (Tumor Promotion Inflammation); abnormal cellular energy (Deregulating Cellular Energetics); genomic instability and mutation (Genome Instability and Mutation). And the avoidance of apoptosis (Evading Apoptosis) in the past was adjusted to be resistant to cell death (Resisting Cell Death). In short, read the full text, can quickly understand the whole picture of oncology and cancer research in the important events, there is no doubt that the article will create a reference to the myth.
Hallmarks of The Next Generation, cell, 2011144 (5): 646-674. (Cancer:)