NCCN guidelines for surgical treatment of stage IV or recurrent metastatic breast cancer 2015v3

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Surgery for IV or Recurrent Metastatic Stage DiseaseSurgical treatment of stage IV or recurrent metastatic diseaseThe primary treatment appr

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Surgery for IV or Recurrent Metastatic Stage Disease

Surgical treatment of stage IV or recurrent metastatic disease

The primary treatment approach recommended by the NCCN Panel for women with metastatic breast cancer and an intact primary tumor is systemic therapy, with consideration of surgery after initial systemic treatment for those women requiring palliation of symptoms or with impending complications such as skin, ulceration, bleeding, fungation, and, pain.

The recommended first-line treatment for women with metastatic breast cancer NCCN expert group of primary tumor resection is not systemic therapy for these women, in the initial systemic therapy to alleviate symptoms and complications such as skin ulcers, bleeding, like mushroom growth and pain, consider surgery.

Generally such surgery be only if local of tumor may be and if other sites obtained of disease are not immediately complete threatening to undertaken life. clearance should

In general, surgery should be performed only if the local tumor is completely removed and the disease in other parts of the body does not immediately threaten life.

Alternatively, radiation therapy be as an option to may surgery. considered

In addition, radiotherapy may be considered as an option for surgery.

Often such surgery collaboration the breast and the surgeon to provide optimal cancer control and surgeon wound closure. reconstructive between requires

Typically, such surgery requires a breast surgeon to work with a plastic surgeon to provide optimal tumor control and wound healing.

Retrospective studies suggest potential benefit from excision of in-breast tumor in select patients with metastatic complete breast cancer. the survival a

A retrospective study has shown the potential survival benefit of complete resection of breast tumors in patients with metastatic breast cancer.

Substantial selection biases in of these and are likely to confound the study results. studies all exist

All of these studies have substantial selection bias, may confuse the results.

Two recent prospective, randomized studies whether not on the tumor in breast is necessary for women who are diagnosed with the metastatic/stage IV breast or assessed cancer. surgery

A recent two prospective, randomized study evaluated the need for surgery for breast cancer in women with metastatic breast cancer.

The results from both studies presented at the San Antonio Breast Cancer 2013 Annual Symposium were similar showing that surgical treatment of primary tumors in women presenting with stage IV disease does not produce an increase in OS.

Similar findings from the two studies at the annual meeting of the Sanantonio breast cancer symposium in showed that women with stage IV disease treated with primary tumors did not improve OS.

Nevertheless, the panel recognizes the need for randomized clinical trials that will address the risks and benefits of local therapy for patients with stage IV disease while eliminating selection biases.

Nevertheless, the panel acknowledges the need for randomized clinical trials to address the risks and benefits of local treatment for patients with stage IV disease, and to eliminate selection bias.

Patient enrollment such trials is in encouraged.

Encourage patients to join the above test.

 

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