Capecitabine (Xeloda) application and precautions

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Capecitabine is an innovative drug in the field of chemotherapy, it has a positive effect in the treatment of colorectal cancer, breast canc

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Capecitabine is an innovative drug in the field of chemotherapy, it has a positive effect in the treatment of colorectal cancer, breast cancer and gastric cancer. Capecitabine itself does not have the ability to kill, only after the activation of TP enzymes in the body, can be transformed into a lethal drug. Because the activity of TP in cancer cells is very high, and the activity of TP in normal tissues is lower, so the capecitabine was activated in cancer cells, the cancer cell killing giant in normal cells is only a small amount of activation, damage of normal cells is very small, the adverse reaction is greatly reduced the.

The main adverse effects of capecitabine were hand foot syndrome and diarrhea:

Grading criteria for hand foot syndrome:

Level 1: hand foot pigmentation, numbness, itching, painless erythema, swelling, does not affect the daily life;

Level 2: pain in the hands and feet of erythema, swelling of the skin, affecting daily life;

Level 3: hand foot skin desquamation, blister, ulcer pain, daily life can not take care of themselves.

Grading standard of diarrhea:

Level 1: Daily defecation increased 4 times;

Level 2: increase the number of daily defecation 4-6 times, or have a night stool;

Level 3: the number of daily bowel movements increased more than 7 times, or fecal incontinence, or the need for external support treatment of intestinal dehydration;

Level 4: the need for intensive care, or hemodynamic crisis;

Encounter these problems, we must seek professional medical help, take comprehensive treatment combining traditional Chinese and Western medicine, do not make use of medicine, so as not to affect the recovery, even affect the normal execution of sequential treatment.

 

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