Small Sanyang patients with entecavir to take a long time?

Navigation:Home > Infectious Medicine > Infected > Small Sanyang patients with entecavir to take a long time?

Peng Jie Department of infection of Nanfang Hospital of Southern Medical University:In 1, before taking the medicine is small three persons,

Content

Peng Jie Department of infection of Nanfang Hospital of Southern Medical University:

In 1, before taking the medicine is small three persons, medication time is quite long. Strictly speaking to Italy, surface antigen negative before the withdrawal, but this is very difficult. Another standard is HBVDNA negative and ALT normal and then continue to consolidate treatment for at least 18 months after withdrawal, but there will be a considerable proportion of rebound or recurrence.

2, must not be halved after stopping the drug, which is unscientific, it is taken for granted, will be more prone to drug resistance.

3, the problem of male medication and fertility is not complicated. Don't worry too much.

4, the proposal: click here to refer to my article "oral anti hepatitis B virus drugs can stop the drug", the proposal: click here to refer to my article "male anti hepatitis B virus treatment of fertility problems"

5, welcome to our hospital, my time for visits: Monday morning, Tuesday afternoon.

Peng Jie Department of infection of Nanfang Hospital of Southern Medical University:

Answer these 5 questions one by one:

1, so far 7 years of data show that the rate of entecavir resistance low. Well tolerated.

2, there must be a way, the treatment is better than not treatment. Don't worry resistance treatment like unworthy, undesirable.

3, resistant virus replication ability is generally weaker than the wild virus.

4, the view that the use of lamivudine is not scientific, there is no scientific basis, it is taken for granted.

5, how long the withdrawal of fertility, no human experimental data, it is impossible to have this data, because the human body itself is immoral. But the theory is supposed to be safe in about 2 weeks.

Patient: description of the disease (time of onset, the main symptoms, hospital etc.): college admissions for the big three, parents and sister for surface antibody positive, but the sister for "small Sanyang", I do not know why a and B are involved? But obviously my hepatitis B is not mother to child transmission. Virus type B. In October 08 the incidence (alanine enzyme 551), in the professional hospital has Pegasys treatment for 4 months, PegIntron for 3 months, due to the hospital every time with the first month interferon while reducing transaminase enzyme, until close to 40 before you discharged, the treatment effect is not good, although to "small three", but the HBVDNA within ten days of the two examination, one for the 6 time, after a 5 time, the doctor said the virus could mutate (I do not know whether the variation test), switching to entecavir after 10 days, DNA dropped to 4, after a time check for 5 months, DNA has been checked out, the liver function is normal,. After the inspection did not check DNA and two half, the enzyme has been reduced to 9 months to $15. Now the drug for 19 months, the liver function is normal, "2 Yang" (expert consultant, said it is not sensitive test method by inspection may still be small three sensitive method) as unmarried, I am very concerned about the "small Sanyang" medication period, I see the experts on the answer, some say not less than 30 months, some say not less than 2 - 3 years, it was also said to be suit to the anti positive, is actually a lifelong treatment, although this argument behind the sound, but difficult to implement. You are a big expert, answer questions will also consider the actual implementation, you think how long should be appropriate? After a certain period of time to take a good half or good stop?

Patient: Thank you for taking the time to answer my questions. Your answer makes me more convinced of the idea of "enduring peace" against the virus. But I have the following questions: first, entecavir toxicity to human body, the human body can tolerate long? Can you tolerate 5 years or even 10 years? Two, there are experts in Bowen said, good medicine for a long time the application will also be resistant to the virus strains selected, if the application for a long time, how to do? For the ratio, cross resistance, anti A De Lamy is weak, for the Nobel also don't know when to import, and whether there is no cure? Three, after the withdrawal of the virus rebound, is not the occurrence of drug resistance mutation, there is an article that is resistant to the virus if it is only a rabbit, then become a lion after resistance, is this? Is there any way to monitor the occurrence of drug resistance after drug withdrawal, and to restore the drug before it occurs? Four, some experts believe that when the virus DNA negative after the replication activity is very low, not easy to change, can be changed to a higher rate of drug resistance of Lami, this argument has scientific basis? If the drug resistance after switching, the virus is resistant to the latter drug or the previous drug resistance? Five, in order to birth safety, under certain conditions can be stopped for 3 months -3 weeks, this is the occurrence of drug resistance risk?

 

www.Cure001.comwww.Cure999.com

Cerebral Vascular Disease,Acne,Heart Disease,Deaf,Headache,Std,Condyloma Acuminatum,Fibroid,Pneumonia,Brain Trauma,。 Rehabilitation Blog 

Rehabilitation Blog @ 2017