as we all know, there are two main types of antiviral drugs used in the treatment of chronic hepatitis B: alpha i
as we all know, there are two main types of antiviral drugs used in the treatment of chronic hepatitis B: alpha interferon and nucleoside analogues. Nucleoside analogues because there is no sure course and accepted the stopping criteria, maintenance treatment for a long time, after the withdrawal of most sooner or later recurrence may be severe liver failure, thus severely limits its wide application in clinical practice.
interferon alpha is considered to be the most potent antiviral drug due to its antiviral and immunomodulatory properties. Therefore, in recent years has been highly respected scholars.
but which hepatitis B patients are suitable for antiviral therapy with interferon alpha? For those who are younger, and are unwilling to take medicine for a long time, especially in the age of patients, if no contraindications to interferon can consider the use of interferon alpha.
a large number of clinical studies have shown that patients with good curative effect to the following, that is to say, the following factors are related with the response to interferon, which has the following factors often can achieve good effect:
(1) before treatment, high levels of ALT, serum ALT or AST repeated fluctuations or enzyme activity increased, and ALT increased more than 3 times the upper limit of the normal value of 5 and less than 10 times; or liver tissue inflammation (with obvious inflammation grading in G2 - G4); 2 times jaundice or serum bilirubin is less than the upper limit of the normal value, and not in a rising trend; (2) HBV DNA< 2 * 108 copies / ml; (3) female; (4) short duration; (5) non vertical transmission; (6) the degree of liver fibrosis; (7) compliableness good; (8) no HCV, HDV or HIV infection.
the liver function is normal, but from a variety of clinical manifestations or analysis of liver biopsy confirmed chronic hepatitis, decompensated cirrhosis after hepatitis is relative indications, can decide whether available interferon therapy based on various factors, should follow the experienced expert guidance of a doctor.
if any of the following circumstances, is considered contraindications to interferon:
Severe mental depression, mental disease, uncontrolled epilepsy, autoimmune disease, uncontrolled diabetes, uncontrolled and severe hypertension or cardiac insufficiency, alcohol and drug abuse, decompensated liver disease and Dbil. During pregnancy, during pregnancy should not be banned.