The results of HCV RNA genotyping are helpful to determine the degree of difficulty of treatment and to develop individualized treatment for
The results of HCV RNA genotyping are helpful to determine the degree of difficulty of treatment and to develop individualized treatment for antiviral therapy. For patients with HCV genotype 1, a standard dose of pegylated interferon alpha (Peg-IFN- alpha) combined with Leigh Bhave Lin (RBV) for a period of up to 48 weeks in patients with a sustained virologic response (SVR) of 40% to. For patients with type 2 or type HCV, the patients were able to obtain SVR from 65% to 82% weeks of treatment. The rate of SVR in patients with genotype 2 was slightly higher than that of type 3.
HCV belongs to the family Flaviviridae (Flaviviridae), its genome is a single strand of RNA, suggesting that at present can be divided into 6 genotypes and subtypes, in accordance with international practices, with Arabia digital representation of the HCV genotype, with lowercase letters English genotype (such as 1a, 2b, 3C etc.). Type 1 was a global distribution, accounting for more than 70% of all HCV infections.
The positive rate of anti -HCV was 3.2% in china. The positive rate of anti -HCV was gradually increased with age, from 1 to 50 to 59 years old in the group of age of 3.9%. There was no significant difference between male and female. HCV1b and 2A genotypes are more common in China, of which 1b is the main type, some areas have 1a, 2b and 3b type reports; type 6 mainly in Hongkong and Macao, in the southern border provinces can also be seen in this genotype.
Department of infectious diseases, Hunan People's Hospital