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Chronic hepatitis B patients taking nucleoside (acid) analogs antiviral treatment, when to stop treatment?In patients with chronic hepatitis

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Chronic hepatitis B patients taking nucleoside (acid) analogs antiviral treatment, when to stop treatment?

In patients with chronic hepatitis B nucleoside (acid) analogues (including lamivudine, adefovir, entecavir, and downs etc.) antiviral therapy, the longer course of treatment, high relapse rate after stopping, so not without stopping, should follow the doctor's advice. According to the guidelines for prevention and treatment of chronic hepatitis B in China in 2010, the following criteria can be considered to stop drug:

1, HBeAg positive chronic hepatitis B patients reached HBV in DNA below the detection limit, ALT normalization, HBeAg seroconversion, reconsolidation of at least 1 years (after at least two review, the time interval of 6 months) will remain unchanged, and the total course has at least 2 years, can consider to stop drug, but the extension treatment can reduce the recurrence.

2, HBeAg negative patients with chronic hepatitis B treatment should be longer in HBV to DNA below the detection limit, ALT normal, at least in the consolidation of 1 and a half years (after at least 3 review, the time interval of 6 months) will remain unchanged, and the total course has reached at least 2 and a half years. Due to the high relapse rate after stopping treatment, it can prolong the course of treatment.

 

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