Long service telbivudine affect pregnancy and fetal?

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Patient: description of the disease (time of onset, the main symptom, hospitals, etc): I am 34 years old, female, 92 years of high school ph

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Patient: description of the disease (time of onset, the main symptom, hospitals, etc): I am 34 years old, female, 92 years of high school physical examination of hepatitis B virus, early because of this disease is not fully understanding, only oral hepatinica. Symptoms: fatigue, dry mouth, poor appetite, constipation, liver area up feeling. Antiviral therapy was carried out in Xinjiang Friendship Hospital, Yili Autonomous Region Hospital of traditional Chinese medicine and medical center of Xinjiang medical university. 06 years, 7 times higher aminotransferase, the virus in the side, two on to the end of 06 small Sanyang take A Duff Vee injection of interferon after half a year after taking DNA. Until 09 years after the liver function is normal in stable condition. In May 09, due to fertility problems the doctor advised take raamiah, take half a year without exception, after because I was worried about the impact of drugs by reduced dosage, the pregnancy in October 2010, fatigue, nausea, liver discomfort and other symptoms, check liver function AST:53U/L, ALT:94U/L, DNA in the replication stage, up to 6 times. And resistant to lamivudine. The doctor take telbivudine, nearly three months, not to review. Want to know, whether long-term use of telbivudine has effect on pregnancy and fetus, the doctor also said that you can not stop. When will I be pregnant? If you can not stop pregnant? For 08 years I was pregnant, because eating adefovir, the doctor said to eat this medicine has effects on the fetus, so do people. So I'm really worried because I'm older, I'm stressed out, and I want to have a healthy child. I hope you can give me good advice, thank you very much!

Wang Chunxi: Shangrao Second People's Hospital Department of liver disease of pregnancy patients during the treatment of oral antiviral drugs, if the application is lamivudine or other pregnancy class B drugs (telbivudine or for Nuo Fuwei), in the fully informed of the risks, the pros and cons, patients signed informed consent cases, treatment can be continued. The limited observation time is short of information, lamivudine or other pregnancy class B drugs (telbivudine or medication for Nuo Fuwei) when pregnant, the production of infant observation now is healthy, but the baby with age, what will be in the future, who can answer.

After lamivudine resistance for telbivudine is not appropriate, the long-term resistance rate is very high.

If there is no cirrhosis, can stop telbivudine in close observation of the case, the use of anti-inflammatory drug, such as liver function normal pregnancy. After the birth of the child to consider antiviral treatment.

 

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