Reasonable selection of treatment methods for chronic hepatitis B

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At present, the drug in the treatment of chronic hepatitis B can be divided into three categories: immunomodulatory drugs, antiviral drugs,

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At present, the drug in the treatment of chronic hepatitis B can be divided into three categories: immunomodulatory drugs, antiviral drugs, liver - drug jaundice. Immunomodulatory drugs including interferon, thymosin, vaccine etc.. Antiviral drugs including lamivudine, adefovir, entecavir, telbivudine etc.. Liver - autigo drug for many varieties of Chinese herbal preparation, its main components include cucurbitacin, silymarin, oleanolic acid, glycyrrhizin, matrine; a few synthetic drugs such as adenosine, amino acid, cholic acid and bile Xiong Quyang.

Evidence based medicine (EBM) is the best evidence based medicine, and the best evidence comes from clinical trials rather than experimental studies. The main purpose of clinical trials is two, through human trials, to examine the effectiveness and safety of drugs or indicators. Because the results of clinical trials are directly from patients, the results are the most scientific.

The drug treatment of chronic hepatitis B, most clinical trial evidence of drug has immunomodulatory drugs interferon, thymosin, vaccine and antiviral drug lamivudine, adefovir and entecavir; although the liver - autigo drugs have been widely used in clinic, but rigorously designed clinical trials are not enough.

According to the conclusion of evidence-based medicine and clinical experience, interferon is promoting HBeAg and HBsAg seroconversion drugs with the highest proportion, has improved the efficacy of interferon thymosin effect; lamivudine, adefovir, entecavir, telbivudine in the inhibition of HBVDNA replication, and stable disease is best; Liver - back role of yellow drug despite steady condition no, but the inhibitory effect of HBVDNA, therefore, the stability condition of the effectiveness of co..

Therefore, a reasonable choice of treatment of chronic hepatitis B should be effective for patients with interferon therapy may be the first choice of, interferon; interferon therapy may be invalid or interferon treated patients, the first choice of antiviral drugs; thymosin, vaccine may help to increase the efficacy of interferon or antiviral drugs. For a small number of immune regulation and antiviral were ineffective in patients with liver - drug use jaundice.

 

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