Hepatitis B virus infection and alcohol consumption can cause liver injury, but the location and mechanism of liver injury are different. Pe
Hepatitis B virus infection and alcohol consumption can cause liver injury, but the location and mechanism of liver injury are different. Persistent or recurrent hepatitis activity and long-term, large amounts of alcohol can eventually lead to cirrhosis, liver decompensation and hepatocellular carcinoma, therefore, hepatitis B virus infection should be treated seriously.
First of all, hepatitis B virus infection. According to the hepatitis B virus exist in the body of time, hepatitis B virus infection can be divided into self limiting and persistent infection; if infected hepatitis related symptoms such as fatigue, loss of appetite or yellowing of the skin and / or elevated alanine aminotransferase, called hepatitis B. Hepatitis caused by self limited infection is commonly referred to as acute hepatitis B, which is commonly referred to as chronic hepatitis B. Whether acute or chronic hepatitis B, if the condition is serious, to the extent of the crisis of life, known as severe hepatitis; severe hepatitis patients do not exist drinking problems, does not belong to the contents of this article discussed.
About 70% to 80% of acute hepatitis B and almost 100% of the patients with chronic hepatitis B, the liver is the main damage location near the portal area, the portal area is concentrated area of small vessels in liver and bile ducts, the small vessel refers to the minimum branch of portal vein and hepatic artery, respectively, that at the end of the portal vein and hepatic end artery. At the end of the portal vein and hepatic artery branches end for hepatic sinusoids, similar to other organs in the capillaries, and liver cell direct contact; hepatic sinusoidal synthesis then send terminal hepatic vein, equivalent to other organs and tissues in the small vein. It is necessary to point out that blood is rich in nutrients in portal vein, hepatic artery blood oxygen content is the highest; the direction of blood flow in liver tissue is from the end of the portal vein and hepatic artery after the end of hepatic sinus into terminal hepatic vein. Therefore, the main damage site of hepatitis B is relatively rich and oxygen rich region, which is relatively easy to repair damaged liver cells.
Next, we will introduce the metabolism of alcohol or ethanol and the accompanying liver injury. After ingestion of alcohol, a small part of the lungs through the direct exhaled and discharged directly through the kidneys; most of the need to metabolize in the liver, and ultimately converted to energy to provide the material acetic acid. Liver cells, mainly from the terminal hepatic portal vein around the liver cells is the main site of metabolism of ethanol. In the presence of alcohol dehydrogenase, cytochrome P450 or catalase, mainly ethanol dehydrogenase, ethanol was converted to acetaldehyde and produced a large number of reactive oxygen species. Under the action of aldehyde dehydrogenase, acetaldehyde is converted to acetic acid which can be used by other tissues.
Has the effect of inhibiting fatty acid oxidation of acetaldehyde, resulting in fatty acid accumulation in liver cells, reactive oxygen free radicals caused by lipid peroxidation leads to structural damage and dysfunction of the cell membrane, the two is the main cause of liver cell injury. It should be emphasized that the main part of the liver injury caused by ethanol is relative to the area of "lack of nutrition and hypoxia".
There is no doubt that whether or not hepatitis B virus, a large number of long-term drinking will cause liver damage. In fact, there is a big difference in human metabolism of ethanol, the so-called "long" and "large" is relative; liver reserve function is considerable and the ability of repair, occasional drinking or not drinking, liver problems are usually not serious consequences. Hepatitis B virus infection and drinking can cause liver damage, hepatitis B virus infection should be treated with caution, as far as possible not to drink.
Specifically, not drinking in patients with acute hepatitis B, recovery of patients with acute hepatitis B after 6 months can not drink, because the liver repair time after hepatitis 6 months; chronic hepatitis B activity, whether it is "big Sanyang" or "small three", are not appropriate drinking; were diagnosed with hepatitis B cirrhotic patients, not drinking; chronic hepatitis B virus infection complicated with fatty liver, whether active hepatitis in, were not drinking; due to other diseases such as taking nitroimidazole metronidazole, tinidazole and cephalosporins were not drinking; chronic hepatitis B virus infection with chronic gastrointestinal tract disease or kidney disease, also cannot drink.
However, known as "chronic hepatitis B virus infection of follow-up carriers" for more than 1 years of inspection once every 3 months, liver function, serum alanine transaminase and blood platelet count were normal in the normal reference range at the same time, liver, spleen and gallbladder ultrasound examination showed no abnormality described occasionally in moderate alcohol consumption needs; that is, the "carrier" if accidentally drinking heavily, or hepatitis related symptoms after drinking, the best treatment specialist, check liver function, hepatitis B is considered by the doctor or alcohol injury.