Chronic hepatitis B is not an incurable disease

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"Second liver can cure?" , this is the majority of chronic hepatitis B patients are most concerned about, it is well understood, but there a

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"Second liver can cure?" , this is the majority of chronic hepatitis B patients are most concerned about, it is well understood, but there are a few patients because of this doubt and give up treatment, loss of treatment time, it is a pity.

Indeed, chronic hepatitis B is still a refractory disease, especially in the antiviral aspects there are many difficulties, therefore, that "how much time for" big three are negative "is not realistic, it is not scientific, can not believe.

However, chronic hepatitis B is not an incurable disease. First of all, we should have a psychological orientation to "cure", "big three are negative hepatitis B" is not "cure" standard of our country and the world of the chronic hepatitis B prevention and treatment guidelines are not "big three are negative" this one, guidelines for the prevention and treatment of chronic hepatitis B in China (2010 Edition) proposed for the overall goal is: to maximize the long-term inhibition of HBV (hepatitis B virus), liver necrosis and liver fibrosis reduced inflammatory cells, delaying and reducing liver decompensation, liver cirrhosis, HCC (hepatocellular carcinoma) and its complications, so as to improve the quality of life and prolong the survival time. One of the most fundamental and important is to maximize the long-term inhibition of HBV (hepatitis B virus).

So, after treatment, can achieve this goal?

2009 annual meeting of the European Society of Hepatology, through the current antiviral treatment, chronic hepatitis B can achieve three kinds of curative effect:

1 the basic efficacy of hepatitis B viral load (HBV DNA) can not be detected continuously, which is lower than the detection value. Most hospitals in China the minimum detection value of 1000 or 500 copies / ml, a few hospitals can be lower.

Effect of - 2 satisfied (based on the basic effect on the realization of E -e antigen) serological antibody conversion, commonly known as the "big world" to "small three".

3 ideal therapeutic effect - surface antigen disappearance, or subsequent surface antibody positive, that the realization of surface antigen - surface antibody seroconversion. This is the closest to the complete cure of hepatitis B, the virus is cleared the ideal state.

At present, the treatment level and the international level of chronic hepatitis B in China, the application of existing antiviral drugs, after standard treatment, some patients can achieve satisfactory curative effect or efficacy, some patients can also achieve the ideal.

In conclusion, although refractory chronic hepatitis B, but not cure, the key is to timely and standardized treatment, and with the development of medical science and medical practice experience, the effect will be more and better treatment of hepatitis B.

(author: chief physician, Shanghai public health clinical center)

 

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