Research Progress on treatment of endometriosis with traditional Chinese Medicine

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Research Progress on treatment of endometriosis with traditional Chinese MedicineAffiliated Hospital of Tianjin traditional Chinese Medicine

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Research Progress on treatment of endometriosis with traditional Chinese Medicine

Affiliated Hospital of Tianjin traditional Chinese Medicine Research Institute Wang Guiping

Abstract: Endometriosis (referred to as endometriosis) belongs to the Department of gynaecology refractory disease, Chinese medicine treatment is quite difficult, because of its good effect and low side effect, more and more loved and respected by the majority of patients, this method in recent years Chinese medicine treatment of endometriosis are reviewed, mainly including internal medicine, traditional Chinese medicine, acupuncture and comprehensive therapy.

Key words: Endometriosis Treatment of traditional Chinese Medicine

Endometriosis (referred to as endometriosis) is the other parts of the body functional growth of endometrial tissue outside of the uterine cavity with mucosal disease, is difficult to treat gynecological disease, in recent years, the incidence rate is rising, the pathogenesis has not been clarified, many treatment methods for endometriosis, in addition to the use of traditional Chinese medicine, western medicine and surgery of the existing means, scholars are still actively exploring new therapy of endometriosis. The Chinese medicine because of the advantages of good analgesic effect and side effects were accepted by patients, and the pathological factors of endometriosis is blood stasis, so blood stasis is a traditional Chinese medicine treatment of endometriosis treated with oral decoction method, also have external therapy, acupuncture, and so do the ironing, a review of recent years Chinese medicine treatment of endometriosis in the literature, in order to help clinicians:

1, internal treatment:

1.1 Gufang now: (1) the positive also five soup: Roche [1] endometriosis belongs to Qi deficiency and blood stasis, the decoction treatment can be obtained through regulating qi and blood, not pain. Zhang [2] using the decoction of 49 cases of endometriosis patients, 3 menstrual cycles for 1 course, for taking 2 courses. Results 15 cases were cured, markedly effective in 23 cases, improved in 8 cases, the total effective rate was 93.9%. (2): Didangtang Didang Decoction in the treatment of 58 cases of phlegm heat and blood stasis on endometriosis of uterus by Wu [3], effective in 28 cases, 24 cases were effective, the total efficiency of 89.66%, the curative effect is satisfied, the basic prescription: leech 8g, DL 12g, Puhuang 10g, 8g 15g, Zhechong, peachseed, bell sub 15g, rhubarb 12g, FT 15g, 15g talc, Plantago 12g, Akebia 10g, myrrh 15g. Daily 1 agent, 15d for a course of treatment: short course of treatment for 1 months, the elderly for a course of treatment for a period of 1 to 2. Medication does not accept western medicine treatment. (3): Zhang Guizhi Fuling Capsule [4] the drug applied to help pregnant help patients with endometriosis, it can effectively improve the symptoms and signs of blood stasis, make good preparation for subsequent treatment. Study confirmed that the prescription can improve the blood rheology, promote adhesion and connective tissue lysis, accelerate the absorption of blood stasis; can inhibit activated macrophages produce growth promoting factor and interleukin -1, thereby inhibiting the proliferation and prostaglandin in ectopic endometrium. The [5] uses this capsule in the treatment of endometriosis in 35 cases, 12 cases were cured, 18 cases improved, the total efficiency of 85.7%. (4) shaofuzhuyudecoction: Duchenne [6] that endometriosis associated with kidney deficiency and liver stagnation, the soup with warm and cold, blood stasis, 54 cases of endometriosis and treatment, 40 cases were cured, 6 cases markedly effective in 4 cases, the total efficiency of 92.6%. Xu exhibition [7] with the treatment of endometriosis, daily 1 agent water decoction, 2 times a day, 3 months for 1 courses. The control group on the first day of menstruation for Danazol Capsules, 400mg/d, 3 months for 1 courses. Two groups of drugs were checked in January liver function 1 times. Results the effective rate was 90% in the two groups, but the side effect was significantly lower than that of the lesser abdominal Stasis Decoction, and there was significant difference between the two groups (P < 0.01). (5) Xuefuzhuyu Decoction (capsule): 80 cases of blood stasis capsule in the treatment of endometriosis with dysmenorrhea induced by Xuefu by Liu [8], 3 months for a course of treatment, the total effective rate was 95%. Laboratory examination showed that the Nailfold Microcirculation of patients with endometriosis and the presence of abnormal blood rheology and soluble immune molecules, PGT2a abnormalities in the menstrual period, after treatment were significantly improved (P < 0.01 or P < 0.05). That's the [9] that endometriosis is Qi stagnation, in the treatment of blood stasis, qi stagnation for medicinal, XZD and Biejia 20g, oyster 30g Ruanjiansanjie, Xuan Hu 30g Huoxue Zhitong, satisfactory clinical effect. Chen [10], premenstrual menstrual period cited by Qinggan Decoction, Zhuyu Decoction in the treatment of 5 cases of pulmonary endometriosis patients with blood after the interval, the combination of disease and syndrome differentiation, combining symptom and root cause, and achieved good results. (6): gexiazhuyutang: 124 cases of endometriosis infertility treated with the decoction to [11]'s results, the total efficiency of 92.7%. (7) Jiaweishixiaosan: Khoo [12] with Jiaweishixiaosan treatment of endometriosis in 38 cases, Jiaweishixiaosan: Puhuang wulingzhi 10g, angelica 12g, 10g; 10g chuanxiong, red peony 10g, cinnamon 10g, astragalus root 20g, Achyranthes 15g, born 12g 10g, sunburn, Dipsacus 30g. Dodder 30g, Cyperus 15g, licorice 6G, daily 1 agent, taking 1 weeks before each menstrual cycle. Even for 10d.3 menstrual cycles for 1 course of treatment, 15 cases were cured, 20 cases improved, the total efficiency of 92%. (8): modified four inverse scattered: Wang [13] with addition and subtraction treatment of 57 cases of endometriosis and four inverse scattered, four inverse scattered flavored drug composition: Bupleurum 6G 10g, Rhizoma Corydalis, Radix Paeoniae Alba 15 g, 15 g, 6 g 10g Sanleng, Fructus aurantii Immaturus, Curcuma 10g, Eupolyphaga sinensis 12g, fried turtle shell (at the end of the research 5 g points), 3 G (red pangolin points at the end of the research, 3G (red) 37 points at the end of the research, Astragalus wash) 30 g, licorice 6 G. Results 17 cases were markedly effective, effective in 35 cases, the total effective rate was 91.23%. (9) other: amber powder, Liuhe Tang and Yang Hetang treatment of endometriosis has been reported in [14][15][16].

From the above literature can be seen, the physicians in the selection of prescription in treatment of endometriosis, with blood circulation for the treatment is important, on this basis, or temperature or pass, or repair or cancellation, or oral or topical, and can receive good results.

1.2 self: the physicians according to their clinical experience of a party, according to the dialectical addition and subtraction with the card, also can obtain good clinical effect, and promoting blood circulation and removing blood stasis is the basic treatment principle. Own party summed up the argument basis following categories:

(1) the argument of Li [17]: kidney deficiency and blood stasis endometriosis often have infertility, menstrual disorders and other symptoms of reproductive system, and reproduction, so in the treatment of tonifying kidney and removing blood stasis should be taken into account, thus invigorating the kidney Xiaoyi granule, drug dodder, teasel root, antler frost, cassia twig, Sanleng and Ezhu, red peony, peony bark, Rhizoma Corydalis, Radix Linderae, Poria, licorice (preparation room of Affiliated Hospital of Shanxi University of Traditional Chinese medicine, per gram per pack containing crude drug 3.5G, 4G). Take 2 bags, with 3 times a day, the fifth day of menstruation began taking 3 months as a course of 1. The clinical effect is good, especially in the adjustment of menstruation, improve sexual desire, increase the pregnancy rate, improve lumbosacral pain and other aspects, better than the control group (P < 0.01). Hu [18] to warm the kidney and removing blood stasis in treating kidney deficiency and blood stasis endometriosis in 60 patients, and compared with Guizhi Fuling Capsule, results in improving the clinical symptoms, signs, basal body temperature, pregnancy outcome was better than the control group (P < 0.05), the specific use: after treated with warming kidney and removing blood stasis: Sanleng and Ezhu each 10g, leech 6G, Salvia 15g, Radix Paeoniae Rubra 12g, pangolin scales 10g, 12g seaweed, lujiaopian 10g, Epimedium 12g, radix rehmanniae, dodder, dangshen, Astragalus 15g. During the 3 days before the net, to remove pain: Blood 3G, 10g (package), pollen Typhae hematoxylin 12g, myrrh 6G, Angelica sinensis, radix paeoniae rubra, Rhizoma Corydalis 12g, cinnamon (after) 5g, Lindera 6g. Add: Anal bulge and Cimicifuga rhizome, costusroot, Gleditsia sinensis; nodular mass with kelp, Shijianchuan, the amount of menstrual ophicalcitum, plus 37 more powder. According to the [19] cycle therapy of old Mr. Xia Guicheng proposed, in different stages of the menstrual cycle, different prescription treatment of endometriosis, satisfactory effect. The method for nourishing yin and blood, by the late medicinal: fried Atractylodes, phellodendron, Patrinia, dandelion, Prunella vulgaris, Gallus gallus 10g, sarsaparilla, Fructus malvae, pig Poria cocos 15g. The ovulation period: qi invigorating the kidney and regulating the ovulation drugs, angelica, red peony root, Chinese yam, sweet potato, root, dodder, amethyst, Adenophora each 10g and stone play wear 15g, FT 10g. Premenstrual: Kidney Yang added stasis, medicinal method: fried angelica, red peony, peony bark, tuckahoe, root, dodder 10g, Cnidium each 15g and 15g, through the stone mountain plant 10g. Menstrual period: blood stasis, Qi analgesic drugs, angelica, radix paeoniae rubra, wulingzhi fried: each 10g and motherwort, Qingpi, Rhizoma Corydalis, Cyperus rotundus 10 - 15g, hawthorn, Poria cocos 10g.

(2) with stagnation of liver Qi Lin [20] to argument: Dan-E-Fu-Kang decoction treatment in patients with endometriosis in 72 cases, and 58 cases with nemestran group comparison, results showed no significant effect of the two groups (P > 0.05), but the two groups after treatment serum CA125 results were more significant (P < 0.05) improvement of symptoms; the treatment group than the control group; Dan-E-Fu-Kang Decoction with fewer side effects, and the pregnancy rate is nemestran. Dan-E-Fu-Kang Decoction by Salvia miltiorrhiza, zedoary, 37, red peony root, bamboo, bupleurum, angelica, Rhizoma sparganii, Rhizoma Cyperi, Rhizoma Corydalis, licorice and other drugs, with blood stasis, liver qi, relieving pain, soft firm of product function. Huang [21] think its pathogenesis is stagnation of liver qi, phlegm and blood stasis, the liver qi, resolving phlegm and removing blood stasis in treatment of endometriosis in 33 cases, control group was treated with danazol treatment, the treatment group than the control group (P < 0.05). The treatment group Neiyi Xiaozheng decoction and its composition: Salvia 10g, 10g of radix curcumae, Radix Paeoniae Rubra 10g, Cyathula root 5g, 15g, 15g, 10g edulis, Fritillaria thunbergii, perilla 10g, Fructus aurantii 5g, pinellia 6G, Kawa Ko 15g.

(3) with phlegm and Blood Stasis Theory: Duan [22] believes that this disease is endogenous phlegm, blood stasis cell pulse, so the use of blood stasis, sanjiexiaoying disease treatment, satisfactory clinical effect, prescription: blood, 37 5g, 20g Salvia miltiorrhiza, radix paeoniae rubra, paeonol, Fritillaria thunbergii, frankincense myrrh, five wulingzhi 10g, shancigu, coix seed 30g. Wang [23] think that blood stasis is the root cause of endometriosis, more like phlegm, phlegm and blood stasis, coalesce into disease, so with Sanjie Zhentong capsule in treatment of endometriosis in 50 cases with danazol as control, two groups had no significant difference in efficacy, but the treatment group adverse reaction in the control group. Sanjiezhentong capsule: blood, 37, coix seed, Zhejiang fritillaria. Shun's [24] by blood stasis, phlegm 70 cases. Treatment of endometriosis, and Dana were in the treatment group after treatment of patients with clinical symptoms and signs were improved, the total effective rate was 85.7%, 42.2% higher than the control group, and blood stasis, xiaotansanjie method has strong immune regulation function, and can inhibit the the level of endometrial antibody in serum, has definite therapeutic effect on endometriosis dysmenorrhea. Prescription: Angelica, radix paeoniae rubra, Prunella 15g, Rhizoma Chuanxiong, dragon's blood, 37 at the end of each 6G, peachseed, Zhejiang Fritillaria, Fructus aurantii 10g, oyster 30g, tangerine seed, litchi 12g.

(4) with blood stasis and caloric Theory: Sheng's [25] with Quyu Jiedu Decoction in the treatment of blood stasis in knots, falling into 70 intrinsic endometriosis drug cases, the total efficiency of 88.5%, the effect is good. Quyu Jiedu Decoction: Salvia, red peony root, peach kernel, dandelion, Xia Kucao, malt, hawthorn 15g, Eupolyphaga sinensis 10g, leech 6G, honeysuckle, Radix Clematidis, Baimaoteng 20g, Gleditsia sinensis 30g. Zhang [26] red defeated Decoction in the treatment of disease, Huayutongluo the process of activating blood circulation and clearing away heat for a long time, 40 endometriosis patients with stasis and heat of the cases, 7 cases were markedly effective, 30 cases effective, 3 cases ineffective, to improve the symptoms, reduce cyst mass, reduce the good effects such as CA125. Red defeated soup: Sargentgloryvine Stem 18G, Patrinia 30g, Coix 30g, peach 12g, Salvia 15g, Radix Paeoniae Rubra 12g, shikonin 18G, safflower 9g, peony 10g. Usage: 3 times a day, decocted in water for 2 times, the menstrual cycle is a course of treatment, continuous observation of 2 courses. Pan [27] endometriosis disease has long blood stasis with heat performance, so the self menstruation drink in the treatment of 60 cases of blood stasis endometriosis patients, significantly effective, the total efficiency of 92%. Stasis menstruation drink: Sargentgloryvine Stem 18G, Patrinia, Coix 30g, peach 12g, Salvia 15g, Radix Paeoniae Rubra 12g, shikonin 18G, safflower 9g, paeonol 10g.

(5) in the Yang deficiency and blood stasis argument: Pan [28] exhibition that the disease to blood stasis is the most common, so the self-made Wen Tong Tang to warm and cold, remove pain, treatment of patients with Endometriosis Dysmenorrhea in 32 cases, the total efficiency of 91.8%. Wen Tong Tang: Lindera 15g, cinnamon 6G, Wu Zhuyu 10g, Cistanche 10g, turmeric 15g, ghost feather 15g, Verbena 15g, corydalis 10g. [29] Shen's Neiyixiao mixture in the treatment of dysmenorrhea with cold coagulation and blood stasis endometriosis, and found that with danazol contrast, dysmenorrhea Neiyixiao Decoction on control lesions, has good curative effect to eliminate pain. It can restore and maintain the ovarian function, promote ovulation, improve the pregnancy rate, regulate the endocrine and immune system function, no damage to liver function, but reduce the recurrence rate of low Yu Dan. Dysmenorrhea Neiyixiao combination: Angelica, radix paeoniae rubra, 10g, blood 1.5g, three 6G, Artemisia anomala 10g, Radix Paeoniae Alba 30g, agilawood surface 3G, prepared frankincense, sapanwood, Rhizoma Cyperi, cumin 10g, Rhizoma Corydalis, vinegar wulingzhi fried 15g, dodder 30g, licorice 10g, pollen typhae. Avoid taking cold food, in each period starting twelfth days to take the next menstrual cramps third days to stop taking, and even served two courses.

(6) with Qi deficiency and blood stasis argument: Qiu [30] exhibition Yiqihuayu legislation, 30 cases of the creation of anti endometriosis Decoction in the treatment of endometriosis, and compared with danazol in the treatment group, the total effect was 93.33% and 86.67% in the control group, no significant difference, but the side effects of danazol was higher than anti Neiyi decoction. Anti endometriosis soup: Astragalus 20g, dangshen 20g, Rhizoma Chuanxiong, radix paeoniae rubra, peach kernel, safflower, myrrh 10g, angelica 15g, dodder 15g, Epimedium 12g. 30 patients wih [31] Yiqi Huayu Decoction in treating qi deficiency and blood stasis endometriosis, the effective rate was 90%, the effect is good. Yiqihuayu Decoction basic prescription: Astragalus 30g, 15g Poria, Atractylodes 15g, Salvia 15g, angelica 15g, Chuanxiong 12g, Cyperus 12g, Curcuma 12g, orange peel 12g, licorice 6g. According to the experience of the teacher, [32]'s treatment of endometriosis of qi deficiency and blood stasis type with the treatment of eliminating the adverse effects was satisfactory. The physiological characteristics of the women, belt, milk production, and formed the pathological features of deficiency, blood stasis, more stagnation, and endometriosis is a disease of blood stasis syndrome and see. The self-made Xiaoyi drink (composed of astragalus root, Salvia miltiorrhiza, chemical drugs), the clinical total effective rate was 94.44%, in narrow or eliminate chocolate cyst, treatment of dysmenorrhea and irregular menstruation and other symptoms of side effects significantly.

Decoction for the treatment of endometriosis 1.3 single herbs mainly

(1): [33] Wang Resina Draconis in 156 cases of endometriosis patients were randomly divided into 2 groups, blood group were treated with a basic recipe plus blood, the control group only basic services, to observe the curative effect of blood blood stasis endometriosis treatment medicine, the basic prescription is: Salvia 10-15g, angelica 8-10g, Shijianchuan 8-10g. Leech 10g, 8g 8g Sanleng, zedoary, motherwort, 8g. Results: the blood group total effective rate was 92.13%, 46.15% in the control group, the difference has significant curative effect; dracorhodin group is the best chocolate cyst, followed by adenomyosis; one year of follow-up after treatment, the recurrence rate of dracorhodin group was 6.14%, 23.08% in the control group, there was significant difference.

(2): Gu [34] of Tripterygium wilfordii 80 cases of endometriosis patients were randomly divided into Tripterygium group and norethisterone group to the therapeutic effect and mechanism of treatment of pelvic endometriosis, adenomyosis of Tripterygium wilfordii. Results: Tripterygium like norethisterone can lead to clinical amenorrhea, histology, endocrinology, but change is different. Triptolide significantly decreased E2, endometrial atrophy, eutopic and ectopic endometrium atrophy and focal necrosis, clinical amenorrhea, pelvic pain disappeared. Although LH can reduce the level of E2, but it can not reach the level of FSH and increase, the changes caused by Tripterygium Wilfordii Hook up to the pathophysiology of endometriosis and adenomyosis.

(3): Zhu [35] leech Hirudo gentleman medicine for the treatment of abdominal wall scar endometriosis cases, significant effect. The recipe is: leech, red peony root, peach kernel, Gleditsia sinensis, pangolin, seaweed 15g, Salvia 20g, blood 5G.

(4): young [36] that contains Caulis Spatholobi antiendometrial antibody in blood of infertile patients with endometriosis (EMAb), the sensitivity in 56%--75%, its specificity in 90%--100%. He used the nourishing blood Spatholobi, appropriate compatibility can be treated EMAb positive infertile patients with endometriosis, curative effect. Modern pharmacological studies indicate that Caulis Spatholobi could improve microcirculation and enhance energy metabolism and metabolism of the uterus.

2 external treatment: external therapy is one of the treatment of disease of TCM characteristic, the external treatment of endometriosis, mainly in the following:

2.1: Rectal Administration: Markov [37] using self-made Lenge Xiaoji Decoction (Sanleng Ezhu, mountain arrowhead, seaweed, pangolins) residue retention enema, hot compress abdomen, a total of 1-3 courses of treatment, the total effective rate was 96.47%. Enema by direct absorption of rectum, high drug concentration, significant effect. PAT'S [38] that endometriosis especially in the treatment of traditional Chinese Medicine Retention Enema with traditional Chinese medicine is best, their approach is to turn in the filtered liquid medicine bottle, suitable temperature after catheter drainage liquid into the rectum (rectal enema before emptying), in the next morning the best effect of defecation. The application of rectal instillation of [39] in the treatment of Endometriosis Dysmenorrhea, with the oral treatment group as the control, the results of traditional Chinese medicine rectal instillation treatment of dysmenorrhea, curative effect is better than oral treatment, the difference was significant. The control group of traditional Chinese medicine recipe: Sparganium 30g, Curcuma 30g, angelica 30g, Chuanxiong 30g, Salvia 30g, cinnamon 30g, Radix Paeoniae Rubra 30g, 30g etc. 30g, Taiwan Sargentglory, Ukraine 30g 30g 30g, Rhizoma Corydalis, bergamot. Concentrated decoction, rectal instillation, before use; the control group used the above dose reduced to oral dose, by taking a week before menstruation stops. Liu [40] exhibition with different Tong Ning suppository (Sanleng Ezhu, corydalis tuber, Wu Yu, epimeddium, blood etc.) 30 cases of anus in the treatment of endometriosis of pain during intercourse, and compared with danazol group. The results of tongNing suppository group total effectiveness 93.33%, danazol group 91.67%, the two groups had no significant difference in efficacy. Rankian [41] using the nano bolt 21 patients anus in the treatment of endometriosis, all in the net after treatment, 3 months for a course of treatment, the dysmenorrhea, menstrual disorders, rectum irritation symptoms and ultrasound results are improved, the effective rate was 90.5%.

2.2: pelvic administration: Liu [42] exhibition using Tongyu injection in non direct the fallopian tube to the treatment of endometriosis, and selected danazol as control group, treatment for 3 months, the positive rate of the treatment group of clinical symptoms and signs, blood viscosity, CA125, EMAb were decreased the contents of FSH, E2, LH, and P have been adjusted, compared with the control group with significant difference. It can be seen that the pelvic drug delivery method can make the drug directly to the disease. Injection of Tongyu injection is made of Rhizoma curcumae, Rhizoma sparganii, honeysuckle, Scutellaria, Salvia and other traditional Chinese medicine.

2.3: applicationtherapy: Ponzi [43] with Xiaoyi Dan seed navel treatment of pelvic endometriosis in 113 cases. Results: 40 cases were cured, 45 cases markedly effective, 22 cases effective, 6 cases ineffective, the total efficiency of 94.69%. Xiaoyi seed composition: leech 30g, Dan fried pangolin 30g, centipede 4, corydalis 30g, prepared myrrh 30g, rhubarb 35g, fried walnut 30g, safflower 20g, Chuanxiong 25g, Radix 25g, cinnamon 20g, Epimedium 30g, dodder 30g. Medicine is fine, bottled spare. When taking medicine at the end of 10G, in order to reconcile the temperature of boiling water into the group, on Shenque point, cover gauze, adhesive tape fixed. 3 days of dressing change, a course of treatment for the 30 time, after four courses of statistical efficacy. Seven scattered acupoint in 31 cases of endometriosis treated with with Wang's [44], found this Law on dysmenorrhea, irregular menstruation, anal pain, traffic and other symptoms have improved significantly, relatively poor curative effect on ovarian cyst, pelvic tenderness nodules.

3 acupuncture therapy:

3.1: Lu moxibustion [45] in 43 cases of chronic pelvic pain patients (including 28 cases of endometriosis patients) by Moxibustion on Guanyuan, acupuncture combined with acupoint Guanyuan, uterus, Liao, Zusanli, Sanyinjiao, Taichong, machine. Results 14 cases were cured, effective in 21 cases, the total effective rate was 81.4%. The traditional Chinese medicine monkshood, antlers cream, cinnamon, frankincense, excrementum pteropi according to the proportion of 2:2:1:1:1 mixed powder with the grinder (60 mesh), when used with 20% alcohol modulated with mold pressed with a diameter of 3cm and height of 0 5cm of aconite cake; moxa moxa made with a thin bottom diameter of 2 5cm with 2 cm high, heavy mold. AI column 2.5g. Acupoints: Guanyuan, uterine cavity (double) for group A points, Cimiu (double) and Shenshu (double) for the B group. The next day a select group of acupoint acupuncture points. The alternate use. Each Acupoint Moxibustion 2 strong moxibustion during the period. Treatment of 76 cases of endometriosis with warm moxibustion and moxibustion exhibition Liu [46], were chosen as control. Results: the total effective rate of the treatment group 88.16%, control group total effective rate was 64.52%, there was significant difference between the two groups. Warming moxibustion powder: Astragalus, angelica, asarum the sub, clematis, aconite, leaves, and even made of coarse powder. When using 30g, 4cm in diameter copper container, a plurality of small pores at the bottom, add 10% ginger tincture wet light. Acupoints: bilateral channels, four full, Sanyinjiao, moxibustion, acupuncture every 10 minutes, 1 times a day, 10 times for a course of treatment.

3.2: Lee [47] using ear ear with traditional Chinese medicine treatment of Endometriosis Dysmenorrhea in 8 cases, and achieved good results. He believes that the "ear, kidney, renal, women in the relationship between the ear and the Chong, Ren and kidney closely, to regulate the meridians, Chongren function through the ear pressure, improve blood circulation, to achieve the purpose of promoting blood circulation and removing blood stasis. Points: subcortical, endocrine, sympathetic, God door, liver, kidney, internal genitalia, court. Methods: in the 5D began to bury, Vaccaria seed, daily press 3 - 5 times, each time 30min, every 2D in embedding medicine 1 times, two ear treatment a total of 5 times, each 2 menstrual cycles for 1 course of treatment.

3.3: Wang [48] acupoint injection with Compound Danshen injection injection at Zusanli, Sanyinjiao, blood and time mash of 2 points, the alternate point selection, each acupoint injection of 1.5 ml, two groups of a total of 6 points ml, treatment of 21 cases of dysmenorrhea, irregular menstruation rate was 87%, effective rate was 91%.

4: many doctors or combined therapy with acupuncture and medicine for treatment of endometriosis, or a combination of inside and outside, also can achieve good results. Kim [49] in Germany during the study, the combination of acupuncture and medicine for treatment of endometriosis, curative effect. The principle, in his blood circulation for the general principles, and to warm and cold, kidney nourishing, Xiaozhi Tongluo, Shugan Qi, according to different patients and syndrome differentiation, selection of appropriate treatment; the biggest characteristic of acupuncture as symptomatic treatment, is to stimulate and arouse the intrinsic potential of the human body, to limit and eliminate the occurrence and development of disease the. Liu exhibition [50] using internal and external treatment for endometriosis infertility, curative effect. Oral medicine to kidney essence, nourishing kidney Yang Jing Decoction Yangxue Tiaojing (rehmannia root, yam 25g, Cornus officinalis, medlar, Eucommia 20g, Loranthaceae, epimedium, dodder seed, raspberry 15g, angelica, white peony root, tangerine peel by 10g). Enema medicine to blood stasis, Ruanjiansanjie the Hongteng Decoction (Sargentgloryvine, Herba patriniae each 30g, tree peony bark, red peony root, motherwort, Eupatorium 25g, Rhizoma Corydalis, trogopterus dung, rice pollen, 15g, Sanleng and Ezhu, Gleditsia sinensis, pangolin, 10g) enema. Hydrotubation: Houttuynia injection 20ml, gentamicin injection 160 thousand U, dexamethasone 5mg, chymotrypsin 5mg, after 3-7 days after menstruation clean. A total of 120 cases of endometriosis treated triple, the total efficiency of 93.33%. The [51] with Yiqihuayu Bushen method Neiyifang and Enema with traditional Chinese medicine in 36 patients were observed 3 months of treatment, the total efficiency of 91.67%. Yu's Neiyi recipe can not only make the symptoms improved, but also improve the ovarian function. Yu's Neiyi recipe: Astragalus 12g, 15g pollen, peach 12g, leech 9g, Epimedium 12g; enema prescription: Astragalus 9g, Puhuang wulingzhi 9g, 3G 9g, frankincense, myrrh 3G,; topical: Aconitum 9g, Artemisia 9g, Spatholobus 30g, safflower 15g, 20g wind, wrapped with gauze, steaming hot compress abdomen.

From the above review can be seen, the traditional Chinese medicine in the treatment of this disease, the disease and syndrome differentiation, with promoting blood circulation for the treatment of law, many ways of delivery, in relieving clinical symptoms (especially dysmenorrhea, irregular menstruation), has a significant effect on improving symptoms, and no toxic side effect, is worthy of the mining the greater the potential.

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