Cervical intraepithelial neoplasia grade 3 (CIN3) clinicopathological diversity

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The CIN3 class is cervical intraepithelial neoplasia grade 3, this is a very near precancerous lesion, popular terms is standing on the thre


The CIN3 class is cervical intraepithelial neoplasia grade 3, this is a very near precancerous lesion, popular terms is standing on the threshold of cancer, the last line of defense is cervical cancer prevention, treatment outcome of patients in this stage is benign, so the clinical is very important, here I put some international the opinions of experts, brief reports, let more patients have their own scientific knowledge popularization.

According to "PLoS ONE" reported on January 2012]: cervical intraepithelial neoplasia grade 3 (CIN3) clinical and pathological heterogeneity (Hannah P. Yang). Is the distribution of cervical intraepithelial neoplasia in cervical tissue heterogeneous or homogeneous? This is always a problem in academic circles, and in the United States, about 50% - 70% of the CIN3 patients with treatment of excessive LEEP surgery, and excessive treatment for patients with bleeding, infection, cervical scar formation of the cervical canal stenosis and other adverse effects of unnecessary. 2003 - 2007 years at the National Cancer Institute Professor Hannah P. Yang of the University of Oklahoma Health Science Center to select 309 cases of tissue in 975 patients undergoing LEEP in diagnosis of CIN3 patients were retrospectively studied, they put these 309 patients were divided into CIN3+CIN2, CIN+-CIN2+CIN1, true CIN3, CIN3+CIN1 four groups, will remove the LEEP intraoperative tissue slices, each patient tissues were divided into the form of a "12 block face", 2 blocks taken from normal and most severe lesions do molecular research, the remaining 10 blocks respectively by 10 pathologists independently diagnosis. The results showed that according to GIN3 lesion area size and with CIN1, CIN2 for the diagnosis of CIN3 is more accurate; the research about half of the patients with multiple CIN3 lesions distributed in the surface of the cervix, further confirmed that CINs is uniformly distributed on the surface of the cervix, rather than the probability of appearing in cervical at 6 o'clock and 12 o'clock. A large area of cervical true CIN3 is frequently found in older women, has a long history of sexual life, less complex infection of high risk HPV genotypes. The size of CIN3 lesions can predict risk in patients with deterioration. Interestingly, the Hannah P. professor Yang found that HPV16 infection and CIN3 lesion area size, and the higher the frequency can predict early screening CIN3 progress, in addition, the author also pointed out that the clinical detection shows highly lesion results and range of CIN3 disease positive correlation. Hannah P. professor of these research results for the gynecologist to provide more CIN3 diagnostic thinking, designed to effectively reduce the excessive treatment of LEEP therapy, Yang.

(Mao Xiaodan, Fujian Provincial Maternity and Child Care Center, by Sun Pengming)



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