In the family, who should be recommended to detect genes?

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In many patients have such doubts: the patient has cancer, is also necessary for gene detection? Why is it recommended to detect the patient

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In many patients have such doubts: the patient has cancer, is also necessary for gene detection? Why is it recommended to detect the patient's genes? Instead of directly detecting blood relatives.

First of all, aiming at the start of the family with genetic testing is the most meaningful, because the probability of gene family in patients with mutations, detection of patients most likely found mutation in familial and other relatives only on these sites can greatly reduce the detection cost of the whole family, which is the conventional international practice. For patients in the family who have died or the patient is not willing to be tested, the genetic counselors recommend who is first detected. In addition, genetic counselors will help determine the family of other members of the order of detection, the need for testing and what genes should be detected?

Second, mutations in the gene may lead to multiple organ tumors, such as the BRCA1/2 mutation, which increases the risk of ovarian and breast cancer, and increases the risk of contralateral breast cancer. Mutations in the PTEN gene also increase the risk of breast cancer, thyroid cancer and endometrial cancer. So even if it is already a patient, if the gene mutation, still need to be alert to other tumors.

 

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