Professor Liao Ning recommends articles: women with breast cancer worry about genetic risk

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Source: Jagsi R al. Clin Oncol. 2015 May 10; 33 (14): 1584-91. (J)College of Radiology, University of Michigan medical college associate pro

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Source: Jagsi R al. Clin Oncol. 2015 May 10; 33 (14): 1584-91. (J)

College of Radiology, University of Michigan medical college associate professor Reshma tumor Dr. Jagsi pointed out that a large number of women diagnosed with breast cancer patients worry about their genetic risk facing other cancers, or worried about their family members will suffer from cancer.

The researchers explained that genetic testing could help guide prevention, monitoring, family counseling, and the need for high intensity treatment decisions. About 5%~10% of breast cancer patients carry germline mutations and are at risk for other cancers. Such mutations, such as BRCA1 and BRCA2, were found in all racial and ethnic subgroups.

Dr. Jagsi and colleagues used the National Cancer Institute's surveillance, epidemiology and end results (SEER) database, selected from the Losangeles and Detroit area 2005~2007 diagnosed with non metastatic breast cancer of women. The researchers chose to analyze these women 9 months and 4 years after the diagnosis of the two points.

The inclusion of only two sites may limit the applicability of the results, and the limited reliability of self-reported cases and the elimination of male breast cancer also have an impact.

A total of 1536 female patients in the queue, among them, 35% of the patients said their demand for genetic testing, there is strong willingness for genetic testing is more common in young women, the Latino population and a family history of breast cancer in women.

493 patients, who indicated that they had a strong willingness to carry out genetic testing in 196 (39.8%) patients, did not discuss the genetic risk with the physician. It also suggests that minority women with this will be significantly more likely than white women to have this need.

Women who were discussing potential needs were more concerned about the potential needs (24.9% vs, P < 0.001) compared with women who had been diagnosed with cancer recurrence and family members. There was a significant correlation between anxiety and race / ethnicity (P < 0.001). Patients have concerns in proportion to the Spanish speaking Latino the highest (83.1%), followed by the English Department (56.7%), followed by Hispanic white women and black women (38.4%) (31.1%). Several factors associated with the complex nature of racial and ethnic disparities in health care may account for this result.

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