Garlic containing substances can induce ER+/PR+ breast cancer cells "suicide" Guo Qianqian translation

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1 what is the "suicide" behavior? -- apoptosis?Apoptosis is due to internal and external environment changes or death trigger signal caused

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1 what is the "suicide" behavior? -- apoptosis?

Apoptosis is due to internal and external environment changes or death trigger signal caused by related genes under the control of the active cell death process of cells in physiological and pathological conditions, follow their own procedures, process the end of his life, namely "Dutch act" behavior. In physiological condition, it can eliminate the aged cells and potential abnormal growth cells, and play an important role in maintaining the homeostasis. Dysregulation of apoptosis can cause a variety of diseases in human body, and is also one of the important causes of tumor occurrence.

2 tumor cell apoptosis and tumor growth and metastasis

From the nature of the tumor, the occurrence of the tumor is the "death / proliferation" balance of tumor cells is broken, that is, the rate of cell proliferation is greater than the rate of death. In fact, tumor metastasis is no exception, although tumor cells detach from the primary tumor in other human tissues or organs of residence is an important part of tumor metastasis, but not all the "escape" the primary focus of tumor cells can form metastases, only those who stop the proliferation rate of tumor cells in death rate will eventually form a transfer stove. It is obvious that the death of tumor is of great significance to the formation of tumor and metastasis. The apoptosis of tumor cells is one of the main ways of death. In other words, if there is a way to promote tumor cell apoptosis, then this method will block or inhibit tumor growth and metastasis.

3 garlic can induce apoptosis of ER+/PR+ breast cancer cells

Garlic contains sulfur compounds that have been shown to reduce the risk of breast cancer. Animal experiments have shown that the active ingredient in garlic can inhibit DNA synthesis of breast cancer cells, delay its growth, and resist angiogenesis and neovascularization. A new study shows that garlic compounds containing diallyl - two sulfide can also induce apoptosis in ER+/PR+ breast cancer cells.

It was found that the organic sulfur compounds contained in the garlic, including diallyl sulfide, diallyl - two sulfide, diallyl - and - sulfur compounds, such as three. Many organic sulfur compounds have been found to inhibit the growth of breast cancer cells in the cell cycle. Diallyl disulfide (three) has been shown to inhibit the invasion and metastasis of breast cancer cells, thereby delaying the progression of breast cancer.

An organic sulfur compound can be produced in the process of opening or chewing garlic, although it still maintains an anti-tumor component in boiled or processed garlic.

4 latest findings on the study of diallyl - and - two sulfide against breast cancer

The aim of this study was to investigate the effect of diallyl sulfide (two) on the occurrence of breast cancer. The authors carried out a series of studies using (ER+/PR+) MCF-7 breast cancer cell lines. They found that diallyl disulfide two induced apoptosis of MCF-7 cells by inhibiting the growth of cell cycle. Diallyl disulfide two can induce the translocation of phosphatidylserine and activate caspase -3, which can inhibit the proliferation of breast cancer cells.

In further study, the author found that the method of diallyl sulfide two by dose dependent change of Bax, Bcl-2, molecular behavior of Bcl-xL and Bcl-w, which means that the effective ingredients of garlic induced apoptosis of breast cancer cells by Bcl-2 protein family. In addition, the authors found that diallyl disulfide () has the role of histone deacetylase inhibitor (HDACi) in MCF-7 cells. HDACi inhibits tumor growth and induces apoptosis of tumor cells. Finally, the authors concluded that the HDACi nature of diallyl sulfide two may be associated with the induction of apoptosis in breast cancer cells.

 

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