The degree of tumor cell differentiation

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Cancer patients often hear similar "high differentiation squamous cell carcinoma", "low differentiated adenocarcinoma" and other professiona

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Cancer patients often hear similar "high differentiation squamous cell carcinoma", "low differentiated adenocarcinoma" and other professional terms. Most patients often do not understand the meaning of these terms at the beginning of their illness. Now we are going to introduce a very important term for cancer cells -- the degree of tumor cell differentiation (Differentiation). The degree of differentiation refers to the extent to which the tumor cells are close to normal cells. The better differentiation (called "differentiated") means that the normal tissue of tumor cells is close to the corresponding source; and low differentiated cells (called "low differentiation" or "undifferentiated") and the corresponding normal tissue origin difference is bigger, the degree of malignancy is relatively large. According to the degree of tumor differentiation, pathological experts usually divided into three pathological grades, and with the English letter G (on behalf of Grade, that is, differentiation) to express. The higher the level, the worse the degree of cell differentiation. G1, that is, high differentiation, cell differentiation. In general, G1 tumor cell division is slower. G2, that is, differentiation, cell differentiation center. G3, which is poorly differentiated and poorly differentiated. Tumor cell division faster. It can be said that the worse the degree of differentiation of tumor cells, the higher the degree of malignancy, tumor growth is more rapid, and prone to metastasis. Well differentiated tumors generally grow slowly, but not easy to relapse after treatment. However, for different tumors, the degree of differentiation of tumor cells and the prognosis of patients are not necessarily directly related. From the point of view of treatment, some cells with low differentiation are more sensitive to chemotherapy and radiotherapy. In other words, the lower the degree of differentiation, the more likely they are to be treated with chemotherapy. Therefore, the prognosis of the patients with poorly differentiated tumors is better than that of poorly differentiated tumors. For example, the common blood disease lymphoma, some high differentiation lymph cancer by combination therapy of chemotherapy and radiotherapy, the cure rate of up to about 40%. While most of the chronic lymphatic cancer (low differentiation), the development of the disease is often very slow, sustainable for several years or even more than ten years, but the drug treatment of chronic lymphatic cancer but almost no cure effect. Nasopharyngeal carcinoma in the diagnosis and treatment of similar situations. There is no direct correlation between oral squamous cell carcinoma and squamous cell carcinoma. In conclusion, for different tumors, the degree of cell differentiation has different meanings. The degree of differentiation of tumor cells is an important reference data in the diagnosis and treatment of cancer, but the effect of treatment, or the need to combine the type of cancer, staging, treatment methods to determine.

 

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