ASO: breast conserving surgery reduces mortality in patients with stage I breast cancer

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In the annals of surgical oncology published online November 8, 2012 "(Annals of Surgical Oncology) magazine, University of Pennsylvania Sha

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In the annals of surgical oncology published online November 8, 2012 "(Annals of Surgical Oncology) magazine, University of Pennsylvania Shayna L. Showalter et al published an article, an evaluation research on trends in treatment of patients with stage I breast cancer. At present, randomized trials have shown that patients with stage I breast cancer treated with mastectomy, and breast conserving surgery (BCS) and radiotherapy (RT) in the treatment of patients, no survival difference. In order to reduce the local recurrence rate and mortality, radiotherapy is recommended for patients after breast conserving surgery.

The researchers found that the proportion of patients with stage I breast cancer who underwent breast conserving surgery increased gradually over time. In the patients with breast conserving surgery, the proportion of patients who did not receive radiotherapy was more stable. There is a link between the reduction of radiotherapy and the increase in mortality after breast conserving surgery.

Through the surveillance, epidemiology, and end results (SEER) database, the researchers identified 194860 women with stage I breast cancer who were diagnosed between 1988 and 2007. The study also evaluated the related factors of surgical treatment and the application of radiotherapy after breast conserving surgery.

The researchers found that during the period from 1988 to 2007, in patients with stage I breast cancer treated with mastectomy, gradually reduce the proportion of patients. Including mastectomy significant predictors, single / divorced women (P = 0.007) and Caucasian (P < 0.001), estrogen receptor negative (P < 0.001), year of diagnosis earlier (P < 0.001), smaller tumor volume (P < 0.001) and area (P < 0.001). Of the patients who received breast conserving surgery, 20% of patients did not receive radiation therapy, which did not change in time. For not receiving radiotherapy in the treatment of patients, significant predictors included, smaller tumor volume (P < 0.001), African American population (P < 0.001), age (P < 0.001), single / divorced women (P < 0.001), estrogen receptor negative (P & lt; 0.001) and the region (P < 0.001). Compared with patients who did not receive radiotherapy, the survival rate was significantly higher in patients undergoing breast conserving surgery and radiotherapy (P < 0.001).

(from Ding Xiangyuan)

 

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