Compound Berberine Bisulfate Ointment for postoperative pain and promote clinical study of anal fissure healing (Abstract

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[Abstract] Objective To observe the change of Compound Berberine Bisulfate Ointment in the treatment of anal fissure postoperative pain trea

Content

[Abstract] Objective To observe the change of Compound Berberine Bisulfate Ointment in the treatment of anal fissure postoperative pain treatment induced more in terms of value. Methods 120 patients of Quanzhou Hospital of Traditional Chinese Medicine anorectal ~2014 June 2012 May 2009 (all subjects were eligible for inclusion criteria), randomly assigned to Compound Berberine Bisulfate Ointment group (treatment group), Musk Hemorrhoids Ointment group (control group), each group of 60 cases were treated. The relevant indicators were observed, including adverse drug reactions, liver and kidney function changes before and after treatment, as well as the effect of the drug treatment, that is, wound healing, healing time. Results (1) in the treatment group after treatment, no obvious adverse reactions, liver and kidney function damage did not occur; (2) the treatment group at each time point after operation 48h internal analgesic effect was significantly better than the control group, 3 times before the dressing after 0.5h analgesic effect was significantly better than the control group, 48h was significantly less than the dosage of analgesic the control group, the wound healing time was significantly shorter than the control group, there was significant difference (P< 0.01). < span=" " > Compound Berberine Bisulfate Ointment conclusion analgesic effect and healing was significantly better than that of Musk Hemorrhoids Ointment is safe, and in the medication process.

Anal fissure anal canal epithelium specific radioactivity belongs to the non longitudinal ulcer, showed spindle or oval shaped, clinical features for anal skin dehiscence, anal pain appeared periodically, the majority of anal fissure without timely treatment can self-healing [1] Chinese medicine, damaged after anal, meridian, Qi, blood gas to run smoothly and there will be blood stasis, or wound Yin, qi stagnation and blood stasis, pain [2] to anal fissure cured in our hospital by Compound Berberine Bisulfate Ointment for postoperative pain of anal fissure, and achieved good results, report as follows now.

1 materials and methods

1.1 general information

120 patients from Quanzhou Hospital of Traditional Chinese Medicine Coloproctology June 2012 ~2014 year in May, were randomly assigned to the Compound Berberine Bisulfate Ointment group (treatment group), Musk Hemorrhoids Ointment group (control group), treatment group and control group with 60 cases. Two groups of patients with clinical data, no significant difference (P > 0.05).

1.2 inclusion and exclusion criteria

1.3 treatment

After surgical dressing Compound Berberine Bisulfate Ointment (Nanjing Baijingyu Pharmaceutical Co Ltd, H32025526) and Musk Hemorrhoids Ointment (Mayinglong Pharmaceutical Group Limited by Share Ltd, Z42021920) intubation rectum. Specific methods: the drug packed in the anus after defecation, in each time, take the Potassium Permanganate 1:5000 warm water bath 10min ~ 15min, when dressing. Choose good clean saline on the wound, and then on the 1 /d [5] group. Patients with wound healing after stopping medication, during treatment, with fresh fruits and vegetables as the main food, avoid constipation, improve local health work [6]. Prophylactic use of antibiotics 3D.

1.4 observation indexes and methods

Complete remission (CR) patients after treatment, no pain; partial remission (PR): after treatment, the pain than the previous administration significantly improved; mild remission (MR): after treatment, the pain was alleviated before administration; invalid (NC): the patients after treatment compared with before treatment, the pain, no improvement. Efficiency for CR and PR sum.

1.5 statistical methods

Results SPSS 19 statistical software was used for statistical analysis, and the measurement data was expressed in the form of (+ s), and the t test was used. The count data were expressed by the relative number, and the x2 test was used. The test standard was 0.05, P<, and the difference was statistically significant between the two groups (). < p=" " >

2 Results

2.1 the incidence of adverse reactions after treatment in the two groups

The incidence of complications in the observation group was 3.33%, the control group was no significant difference between the two groups (x2 = 1.356, P = 0.508).

Comparison of 2.2 Compound Berberine Bisulfate Ointment group of liver and kidney function

1D and 1W before treatment after treatment to observe the liver function index patients had no significant difference (P> 0.05), shows that Compound Berberine Bisulfate Ointment after treatment no obvious damage to liver and kidney function.

2.3 comparison of analgesic effect

Compound Berberine Bisulfate Ointment group after 4 observation points 48h analgesic effect was significantly better than Musk Hemorrhoids Ointment group, there was significant difference between groups (P< 0.05). < p=" " >

2.4 group of patients before and after the end of the three changes in the analgesic effect of 0.5h points

Compound Berberine Bisulfate Ointment group three times before dressing after 0.5h time analgesic effect was significantly better than Musk Hemorrhoids Ointment group, there was significant difference between groups (P< 0.05). See table 5. < p=" " >

The patients of 2.5 group two 48h after nesso to analgesic dose comparison

Compound Berberine Bisulfate Ointment group after 48h nesso to analgesic was significantly less than that of Musk Hemorrhoids Ointment group, there was significant difference between groups (P< 0.05). < p=" " >

2.6 the wound healing time of the two groups were compared

Compound Berberine Bisulfate Ointment group to shorten the time of wound healing was significantly better than that of Musk Hemorrhoids Ointment group, there was significant difference between groups (P< 0.05). < p=" " >

3 discussion

Chinese medicine known as "anal anus", and soul meal, transfer dregs, also called ass. The "Yellow Emperor" that [9] pomen is also the five internal organs, shall not be kept for a long time water valley. The anus is the body eliminate foul air, turbidity to the new location, to control the body dirty gas, but also affect the body's dirty gas. Patients with anal fissure surgery after surgery because of the cut, causing damage to the tissue and nerve tissue, the anal sphincter is stimulated, and thus the occurrence of contraction, spasm, causing pain to the body. After the body is damaged, it will release a variety of inflammatory mediators, mainly pain factor, making the body pain, these are the basis of the incidence of anal pain. After anorectal surgery, the patient pain due to wound, also because of postoperative defecation, touch and pain, increase the patient's pain.

Anal fissure wound healing process is complex, the longer time required. Patients with anal fissure in the perioperative period, to pay attention to the reasonable diet, diet will be appropriate, not only can promote the smooth operation, but also can promote the wound recovery after operation. In addition, a reasonable diet can also reduce pain, reduce the pain of patients, but also can reduce the incidence of complications. Under normal circumstances, you can add some nutrients, such as protein rich foods. Patients should also do a good job of personal hygiene, reduce the possibility of infection. Anal fissure affected by systemic factors. When there are some patients with anemia, diabetes and other conditions, there will be slow wound healing, wound healing time, etc.. When the patient's local infection occurs, there will be a delay in wound healing. The infection will make granulation tissue necrosis, liquefaction of wound, inflammatory substances not promptly removed, refractory wound.

Through this study can be seen in the observation group postoperative analgesic effect and wound healing time were significantly better than the control group, wound healing, dampness can Qingrejiedu, Liangxue hemostatic, detumescence and analgesic effect.

At the same time, the results of this study found that can protect liver and kidney function in patients after treatment of compound berberine hydrosulphate. Compound berberine hydrosulphate can prevent the reduction of renal blood flow and protect renal tubule function, and lysosomal membrane stability and antagonistic effect of neutrophil elastase, so there is a clear prevention of renal damage after liver resection and acute renal failure.

In summary, compound berberine hydrosulphate applied to promote the analgesia of postoperative anal fissure healing has good curative effect, less adverse reactions, it is worthy of clinical use.

References (omitted)

Journal of Chinese medical science 2015, 5 (): 30-33, 95

 

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