The principle of 2--- male reproductive system immune infertility of the blood testis barrier

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1, structure: the blood testis barrier by strong adjacent supporting cells at the base of the closely connected, including vascular endothel

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1, structure: the blood testis barrier by strong adjacent supporting cells at the base of the closely connected, including vascular endothelial basement membrane and connective tissue and seminiferous tubules. 2, function: prevent sperm contact with the immune system, so that the lymphocytes can not identify the sperm plasma antigen, under normal circumstances, the sperm is blocked in the pipeline of male reproductive closed, isolated from the immune system become blocked antigen does not cause immune reaction. Once the weak blood testis barrier such as rete testis, epididymis, infection, trauma and so on are output tubular damage, leakage of lymphatic antigen into the blood by lymphocyte antigen recognition, immune reaction to produce anti sperm antibodies, such as the formation of epididymal nodules, blockage of the vas deferens (and completely blocked), brake antibody formation of sperm sterility.

 

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